Quality Control: Linking Retrotranslocation and Degradation

Colin J. Stirling, John Michael Lord

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Misfolded proteins in the ER require the p97 AAA ATPase for dislocation across the membrane prior to degradation by the cytosolic proteasome. The mechanism by which dislocated proteins are delivered to the proteasome from p97 is unclear, but recent studies suggest an important regulatory role for the protein ataxin-3.
Original languageEnglish
Pages (from-to)R1035-R1037
Number of pages3
JournalCurrent Biology
Volume16
Issue number24
DOIs
Publication statusPublished - 2006

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