Quality Control: Linking Retrotranslocation and Degradation

Colin J. Stirling; John Michael Lord

doi:10.1016/j.cub.2006.11.013

Quality Control: Linking Retrotranslocation and Degradation

Colin J. Stirling
, John Michael Lord

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Misfolded proteins in the ER require the p97 AAA ATPase for dislocation across the membrane prior to degradation by the cytosolic proteasome. The mechanism by which dislocated proteins are delivered to the proteasome from p97 is unclear, but recent studies suggest an important regulatory role for the protein ataxin-3.

Original language	English
Pages (from-to)	R1035-R1037
Number of pages	3
Journal	Current Biology
Volume	16
Issue number	24
DOIs	https://doi.org/10.1016/j.cub.2006.11.013
Publication status	Published - 2006

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title = "Quality Control: Linking Retrotranslocation and Degradation",

abstract = "Misfolded proteins in the ER require the p97 AAA ATPase for dislocation across the membrane prior to degradation by the cytosolic proteasome. The mechanism by which dislocated proteins are delivered to the proteasome from p97 is unclear, but recent studies suggest an important regulatory role for the protein ataxin-3.",

author = "Stirling, \{Colin J.\} and Lord, \{John Michael\}",

year = "2006",

doi = "10.1016/j.cub.2006.11.013",

language = "English",

volume = "16",

pages = "R1035--R1037",

journal = "Current Biology",

issn = "0960-9822",

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T1 - Quality Control: Linking Retrotranslocation and Degradation

AU - Stirling, Colin J.

AU - Lord, John Michael

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AB - Misfolded proteins in the ER require the p97 AAA ATPase for dislocation across the membrane prior to degradation by the cytosolic proteasome. The mechanism by which dislocated proteins are delivered to the proteasome from p97 is unclear, but recent studies suggest an important regulatory role for the protein ataxin-3.

U2 - 10.1016/j.cub.2006.11.013

DO - 10.1016/j.cub.2006.11.013

M3 - Article

SN - 0960-9822

VL - 16

SP - R1035-R1037

JO - Current Biology

JF - Current Biology

IS - 24

ER -

Quality Control: Linking Retrotranslocation and Degradation

Abstract

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