Quantitative imaging of the human upper airway: Instrument design and clinical studies

M. S. Leigh; J. J. Armstrong; A. Paduch; D. D. Sampson; J. H. Walsh; D. R. Hillman; P. R. Eastwood

doi:10.1117/12.696987

Quantitative imaging of the human upper airway: Instrument design and clinical studies

M. S. Leigh, J. J. Armstrong, A. Paduch, D. D. Sampson, J. H. Walsh, D. R. Hillman, P. R. Eastwood

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Imaging of the human upper airway is widely used in medicine, in both clinical practice and research. Common imaging modalities include video endoscopy, X-ray CT, and MRI. However, no current modality is both quantitative and safe to use for extended periods of time. Such a capability would be particularly valuable for sleep research, which is inherently reliant on long observation sessions. We have developed an instrument capable of quantitative imaging of the human upper airway, based on endoscopic optical coherence tomography. There are no dose limits for optical techniques, and the minimally invasive imaging probe is safe for use in overnight studies. We report on the design of the instrument and its use in preliminary clinical studies, and we present results from a range of initial experiments. The experiments show that the instrument is capable of imaging during sleep, and that it can record dynamic changes in airway size and shape. This information is useful for research into sleep disorders, and potentially for clinical diagnosis and therapies.

Original language	English
Title of host publication	Saratov Fall Meeting 2005
Subtitle of host publication	Optical Technologies in Biophysics and Medicine VII
Editors	Valery V. Tuchin
Publisher	SPIE
Number of pages	8
ISBN (Print)	0819462152, 9780819462152
DOIs	https://doi.org/10.1117/12.696987
Publication status	Published - 2006
Externally published	Yes
Event	Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII - Saratov, Russian Federation Duration: 27 Sept 2005 → 30 Sept 2005

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6163
ISSN (Print)	1605-7422

Conference

Conference	Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Country/Territory	Russian Federation
City	Saratov
Period	27/09/05 → 30/09/05

Bibliographical note

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

Endoscopy
Optical Coherence Tomography
Sleep Apnoea

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Leigh, M. S., Armstrong, J. J., Paduch, A., Sampson, D. D., Walsh, J. H., Hillman, D. R., & Eastwood, P. R. (2006). Quantitative imaging of the human upper airway: Instrument design and clinical studies. In V. V. Tuchin (Ed.), Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII [61630O] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6163). SPIE. https://doi.org/10.1117/12.696987

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Leigh, MS, Armstrong, JJ, Paduch, A, Sampson, DD, Walsh, JH, Hillman, DR & Eastwood, PR 2006, Quantitative imaging of the human upper airway: Instrument design and clinical studies. in VV Tuchin (ed.), Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII., 61630O, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6163, SPIE, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, Saratov, Russian Federation, 27/09/05. https://doi.org/10.1117/12.696987

Quantitative imaging of the human upper airway : Instrument design and clinical studies. / Leigh, M. S.; Armstrong, J. J.; Paduch, A. et al.

Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII. ed. / Valery V. Tuchin. SPIE, 2006. 61630O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6163).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Leigh MS, Armstrong JJ, Paduch A, Sampson DD, Walsh JH, Hillman DR et al. Quantitative imaging of the human upper airway: Instrument design and clinical studies. In Tuchin VV, editor, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII. SPIE. 2006. 61630O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.696987

Quantitative imaging of the human upper airway: Instrument design and clinical studies

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Bibliographical note

Keywords

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