Quantitative imaging of the human upper airway: Instrument design and clinical studies

M. S. Leigh, J. J. Armstrong, A. Paduch, D. D. Sampson, J. H. Walsh, D. R. Hillman, P. R. Eastwood

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Imaging of the human upper airway is widely used in medicine, in both clinical practice and research. Common imaging modalities include video endoscopy, X-ray CT, and MRI. However, no current modality is both quantitative and safe to use for extended periods of time. Such a capability would be particularly valuable for sleep research, which is inherently reliant on long observation sessions. We have developed an instrument capable of quantitative imaging of the human upper airway, based on endoscopic optical coherence tomography. There are no dose limits for optical techniques, and the minimally invasive imaging probe is safe for use in overnight studies. We report on the design of the instrument and its use in preliminary clinical studies, and we present results from a range of initial experiments. The experiments show that the instrument is capable of imaging during sleep, and that it can record dynamic changes in airway size and shape. This information is useful for research into sleep disorders, and potentially for clinical diagnosis and therapies.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2005
Subtitle of host publicationOptical Technologies in Biophysics and Medicine VII
EditorsValery V. Tuchin
PublisherSPIE
Number of pages8
ISBN (Print)0819462152, 9780819462152
DOIs
Publication statusPublished - 2006
Externally publishedYes
EventSaratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII - Saratov, Russian Federation
Duration: 27 Sep 200530 Sep 2005

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6163
ISSN (Print)1605-7422

Conference

ConferenceSaratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Country/TerritoryRussian Federation
CitySaratov
Period27/09/0530/09/05

Bibliographical note

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • Endoscopy
  • Optical Coherence Tomography
  • Sleep Apnoea

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