Quantitative modelling of sleep dynamics

P A Robinson; A J K Phillips; B D Fulcher; M Puckeridge; J A Roberts

doi:10.1098/rsta.2011.0120

Quantitative modelling of sleep dynamics

P A Robinson, A J K Phillips, B D Fulcher, M Puckeridge, J A Roberts

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

Arousal is largely controlled by the ascending arousal system of the hypothalamus and brainstem, which projects to the corticothalamic system responsible for electroencephalographic (EEG) signatures of sleep. Quantitative physiologically based modelling of brainstem dynamics theory is described here, using realistic parameters, and links to EEG are outlined. Verification against a wide range of experimental data is described, including arousal dynamics under normal conditions, sleep deprivation, stimuli, stimulants and jetlag, plus key features of wake and sleep EEGs.

Original language	English
Pages (from-to)	3840-3854
Number of pages	15
Journal	Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume	369
Issue number	1952
DOIs	https://doi.org/10.1098/rsta.2011.0120
Publication status	Published - 13 Oct 2011
Externally published	Yes

Keywords

Ascending arousal system
Chronotype
Electroencephalography
Modelling
Sleep-wake cycle

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10.1098/rsta.2011.0120Licence: In Copyright

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JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

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Quantitative modelling of sleep dynamics

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Keywords

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