Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

Tong Chen, Ni Xie, Lucia Viglianti, Yabin Zhou, Hui Tan, Ben Tang, Youhong Tang

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

    Original languageEnglish
    Pages (from-to)351-362
    Number of pages12
    JournalFaraday Discussions
    Volume196
    DOIs
    Publication statusE-pub ahead of print - 2017

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