Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

Tong Chen; Ni Xie; Lucia Viglianti; Yabin Zhou; Hui Tan; Ben Tang; Youhong Tang

doi:10.1039/c6fd00153j

Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

Tong Chen, Ni Xie, Lucia Viglianti, Yabin Zhou, Hui Tan, Ben Tang, Youhong Tang

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

Original language	English
Pages (from-to)	351-362
Number of pages	12
Journal	Faraday Discussions
Volume	196
Early online date	2017
DOIs	https://doi.org/10.1039/c6fd00153j
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c6fd00153jLicence: CC BY

Cite this

@article{b054e71ee119440b909686e553c84c03,

title = "Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease",

abstract = "Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.",

author = "Tong Chen and Ni Xie and Lucia Viglianti and Yabin Zhou and Hui Tan and Ben Tang and Youhong Tang",

year = "2017",

doi = "10.1039/c6fd00153j",

language = "English",

volume = "196",

pages = "351--362",

journal = "Faraday Discussions",

issn = "1364-5498",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

AU - Chen, Tong

AU - Xie, Ni

AU - Viglianti, Lucia

AU - Zhou, Yabin

AU - Tan, Hui

AU - Tang, Ben

AU - Tang, Youhong

PY - 2017

Y1 - 2017

N2 - Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

AB - Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

UR - http://pubs.rsc.org/-/content/articlehtml/2016/fd/c6fd00153j

UR - http://www.scopus.com/inward/record.url?scp=85013782850&partnerID=8YFLogxK

U2 - 10.1039/c6fd00153j

DO - 10.1039/c6fd00153j

M3 - Article

SN - 1364-5498

VL - 196

SP - 351

EP - 362

JO - Faraday Discussions

JF - Faraday Discussions

ER -

Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this