Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk

John A. Kanis, Nicholas C. Harvey, Mattias Lorentzon, Enwu Liu, Marian Schini, Bo Abrahamsen, Jonathan D. Adachi, Majed Alokail, Fredrik Borgstrom, Olivier Bruyère, John J. Carey, Patricia Clark, Cyrus Cooper, Elizabeth M. Curtis, Elaine M. Dennison, Manuel Díaz-Curiel, Hans P. Dimai, Daniel Grigorie, Mickael Hiligsmann, Patricia KhashayarWillem Lems, E. Michael Lewiecki, Roman S. Lorenc, Alexandra Papaioannou, Jean Yves Reginster, René Rizzoli, Eric Shiroma, Stuart L. Silverman, Eleanor Simonsick, Manuel Sosa-Henríquez, Pawel Szulc, Kate A. Ward, Noriko Yoshimura, Helena Johansson, Liesbeth Vandenput, Eugene V. McCloskey, Board of IOF, and the IOF Working Group on Epidemiology and Quality of Life

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Task Force on 'Clinical Algorithms for Fracture Risk' commissioned by the American Society for Bone and Mineral Research (ASBMR) Professional Practice Committee has recommended that FRAX® models in the US do not include adjustment for race and ethnicity. This position paper finds that an agnostic model would unfairly discriminate against the Black, Asian and Hispanic communities and recommends the retention of ethnic and race-specific FRAX models for the US, preferably with updated data on fracture and death hazards. In contrast, the use of intervention thresholds based on a fixed bone mineral density unfairly discriminates against the Black, Asian and Hispanic communities in the US. This position of the Working Group on Epidemiology and Quality of Life of the International Osteoporosis Foundation (IOF) is endorsed both by the IOF and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Original languageEnglish
Pages (from-to)1487-1496
Number of pages10
JournalOsteoporosis international : with other metabolic bone diseases
Volume35
Issue number9
DOIs
Publication statusPublished - Sept 2024
Externally publishedYes

Keywords

  • Fracture probability
  • FRAX adjustment
  • Race and ethnicity
  • Racism

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