Radiation senstitivity of human lyphocytes

Robert Kultaca, Susan J. Alder, Ram S. Seshadri, Alexander A. Morley

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A simple and rapid in vitro techinique to assess the sensitivity of human lymphocytes to X- and UV-radiation is decribes. Periphaela blood lymphocytes are cloned in agar and colony survival us used as the end point. Survival down to a fraction of apporox. 0.02 can be measures accurately. The D10 for X- radiation is apporox. 165 rad and the initial portion of the survival curve is linear with no evidence of a threshold. The D10 for UV-radiation is approx. 50 erg/mm2. The technique should be of value both for general radiobiological studies and fro detecting individuals having abnormalities of DNA repair.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume94
Issue number1
DOIs
Publication statusPublished - May 1982
Externally publishedYes

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