Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

Raizulnasuha Abdul Rashid; Safri Zainal Abidin; Muhammad Afiq Khairil Anuar; Takahiro Tominaga; Hiroaki Akasaka; Ryohei Sasaki; Katahira Kie; Khairunisak Abdul Razak; Binh T.T. Pham; Brian S. Hawkett; Mary Ann Carmichael; Moshi Geso; Wan Nordiana Rahman

doi:10.1016/j.onano.2018.100027

Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

Raizulnasuha Abdul Rashid
, Safri Zainal Abidin
, Muhammad Afiq Khairil Anuar
, Takahiro Tominaga
, Hiroaki Akasaka
, Ryohei Sasaki
, Katahira Kie
, Khairunisak Abdul Razak
, Binh T.T. Pham
, Brian S. Hawkett
, Mary Ann Carmichael
, Moshi Geso
, Wan Nordiana Rahman

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Radiosensitization effects caused by high atomic number (Z) metallic nanoparticles have been extensively explored with a wide range of X-ray based radiotherapy beams that seem to provide intriguing results for potential clinical applications. In this study, the radiobiological consequences of gold nanoparticles (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), Platinum Nanodendrites (PtNDs) and Bismuth Oxide Nanorods (BiNRs) on Human Colon Carcinoma cells (HCT 116) irradiated with 150 MeV proton beams were investigated. Cell survival and reactive oxygen species (ROS) generation were measured. BiNRs demonstrates the highest sensitization enhancement ratio (SER) of 4.93 followed by PtNDs with SER value of 3.08. Meanwhile, AuNPs and SPIONs depict SER values around 2.64 and 1.95 respectively. The ROS generation corresponded to the level of radiosensitization with the highest ROS obtained for BiNRs and followed by PtNDs, AuNPs and SPIONs. In conclusion, high Z nanoparticles possess the potential to be clinically applied in proton beam therapy.

Original language	English
Article number	100027
Number of pages	8
Journal	OpenNano
Volume	4
DOIs	https://doi.org/10.1016/j.onano.2018.100027
Publication status	Published - 1 Jan 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bismuth nanoparticles
Gold nanoparticles
Platinum nanoparticles
Proton beam
Radiosensitization
Superparamagnetic iron oxide nanoparticles

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10.1016/j.onano.2018.100027Licence: CC BY-NC-ND

Final published versionFinal published version, 929 KBLicence: CC BY-NC-ND

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Abdul Rashid, R., Zainal Abidin, S., Khairil Anuar, M. A., Tominaga, T., Akasaka, H., Sasaki, R., Kie, K., Abdul Razak, K., Pham, B. T. T., Hawkett, B. S., Carmichael, M. A., Geso, M., & Rahman, W. N. (2019). Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam. OpenNano, 4, Article 100027. https://doi.org/10.1016/j.onano.2018.100027

@article{c4c9841ae93340dabc9d07cc49852995,

title = "Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam",

abstract = "Radiosensitization effects caused by high atomic number (Z) metallic nanoparticles have been extensively explored with a wide range of X-ray based radiotherapy beams that seem to provide intriguing results for potential clinical applications. In this study, the radiobiological consequences of gold nanoparticles (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), Platinum Nanodendrites (PtNDs) and Bismuth Oxide Nanorods (BiNRs) on Human Colon Carcinoma cells (HCT 116) irradiated with 150 MeV proton beams were investigated. Cell survival and reactive oxygen species (ROS) generation were measured. BiNRs demonstrates the highest sensitization enhancement ratio (SER) of 4.93 followed by PtNDs with SER value of 3.08. Meanwhile, AuNPs and SPIONs depict SER values around 2.64 and 1.95 respectively. The ROS generation corresponded to the level of radiosensitization with the highest ROS obtained for BiNRs and followed by PtNDs, AuNPs and SPIONs. In conclusion, high Z nanoparticles possess the potential to be clinically applied in proton beam therapy.",

keywords = "Bismuth nanoparticles, Gold nanoparticles, Platinum nanoparticles, Proton beam, Radiosensitization, Superparamagnetic iron oxide nanoparticles",

author = "\{Abdul Rashid\}, Raizulnasuha and \{Zainal Abidin\}, Safri and \{Khairil Anuar\}, \{Muhammad Afiq\} and Takahiro Tominaga and Hiroaki Akasaka and Ryohei Sasaki and Katahira Kie and \{Abdul Razak\}, Khairunisak and Pham, \{Binh T.T.\} and Hawkett, \{Brian S.\} and Carmichael, \{Mary Ann\} and Moshi Geso and Rahman, \{Wan Nordiana\}",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.onano.2018.100027",

language = "English",

volume = "4",

journal = "OpenNano",

issn = "2352-9520",

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}

Abdul Rashid, R, Zainal Abidin, S, Khairil Anuar, MA, Tominaga, T, Akasaka, H, Sasaki, R, Kie, K, Abdul Razak, K, Pham, BTT, Hawkett, BS, Carmichael, MA, Geso, M & Rahman, WN 2019, 'Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam', OpenNano, vol. 4, 100027. https://doi.org/10.1016/j.onano.2018.100027

TY - JOUR

T1 - Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

AU - Abdul Rashid, Raizulnasuha

AU - Zainal Abidin, Safri

AU - Khairil Anuar, Muhammad Afiq

AU - Tominaga, Takahiro

AU - Akasaka, Hiroaki

AU - Sasaki, Ryohei

AU - Kie, Katahira

AU - Abdul Razak, Khairunisak

AU - Pham, Binh T.T.

AU - Hawkett, Brian S.

AU - Carmichael, Mary Ann

AU - Geso, Moshi

AU - Rahman, Wan Nordiana

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Radiosensitization effects caused by high atomic number (Z) metallic nanoparticles have been extensively explored with a wide range of X-ray based radiotherapy beams that seem to provide intriguing results for potential clinical applications. In this study, the radiobiological consequences of gold nanoparticles (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), Platinum Nanodendrites (PtNDs) and Bismuth Oxide Nanorods (BiNRs) on Human Colon Carcinoma cells (HCT 116) irradiated with 150 MeV proton beams were investigated. Cell survival and reactive oxygen species (ROS) generation were measured. BiNRs demonstrates the highest sensitization enhancement ratio (SER) of 4.93 followed by PtNDs with SER value of 3.08. Meanwhile, AuNPs and SPIONs depict SER values around 2.64 and 1.95 respectively. The ROS generation corresponded to the level of radiosensitization with the highest ROS obtained for BiNRs and followed by PtNDs, AuNPs and SPIONs. In conclusion, high Z nanoparticles possess the potential to be clinically applied in proton beam therapy.

AB - Radiosensitization effects caused by high atomic number (Z) metallic nanoparticles have been extensively explored with a wide range of X-ray based radiotherapy beams that seem to provide intriguing results for potential clinical applications. In this study, the radiobiological consequences of gold nanoparticles (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), Platinum Nanodendrites (PtNDs) and Bismuth Oxide Nanorods (BiNRs) on Human Colon Carcinoma cells (HCT 116) irradiated with 150 MeV proton beams were investigated. Cell survival and reactive oxygen species (ROS) generation were measured. BiNRs demonstrates the highest sensitization enhancement ratio (SER) of 4.93 followed by PtNDs with SER value of 3.08. Meanwhile, AuNPs and SPIONs depict SER values around 2.64 and 1.95 respectively. The ROS generation corresponded to the level of radiosensitization with the highest ROS obtained for BiNRs and followed by PtNDs, AuNPs and SPIONs. In conclusion, high Z nanoparticles possess the potential to be clinically applied in proton beam therapy.

KW - Bismuth nanoparticles

KW - Gold nanoparticles

KW - Platinum nanoparticles

KW - Proton beam

KW - Radiosensitization

KW - Superparamagnetic iron oxide nanoparticles

UR - https://www.scopus.com/pages/publications/85058109364

U2 - 10.1016/j.onano.2018.100027

DO - 10.1016/j.onano.2018.100027

M3 - Article

AN - SCOPUS:85058109364

SN - 2352-9520

VL - 4

JO - OpenNano

JF - OpenNano

M1 - 100027

ER -

Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

Abstract

UN SDGs

Keywords

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