RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

Jingquan Liu, Lei Tao, Jiangtao Xu, Zhongfan Jia, Cyrille Boyer, Thomas P. Davis

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS).

Original languageEnglish
Pages (from-to)4455-4463
Number of pages9
JournalPolymer
Volume50
Issue number19
DOIs
Publication statusPublished - 10 Sep 2009
Externally publishedYes

Keywords

  • Biodegradable polymer
  • RAFT
  • Star polymer

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