RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

Jingquan Liu; Lei Tao; Jiangtao Xu; Zhongfan Jia; Cyrille Boyer; Thomas P. Davis

doi:10.1016/j.polymer.2009.07.018

RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

Jingquan Liu, Lei Tao, Jiangtao Xu, Zhongfan Jia, Cyrille Boyer, Thomas P. Davis

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS).

Original language	English
Pages (from-to)	4455-4463
Number of pages	9
Journal	Polymer
Volume	50
Issue number	19
DOIs	https://doi.org/10.1016/j.polymer.2009.07.018
Publication status	Published - 10 Sept 2009
Externally published	Yes

Keywords

Biodegradable polymer
RAFT
Star polymer

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10.1016/j.polymer.2009.07.018Licence: In Copyright

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title = "RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology",

abstract = "Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS).",

keywords = "Biodegradable polymer, RAFT, Star polymer",

author = "Jingquan Liu and Lei Tao and Jiangtao Xu and Zhongfan Jia and Cyrille Boyer and Davis, {Thomas P.}",

year = "2009",

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doi = "10.1016/j.polymer.2009.07.018",

language = "English",

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TY - JOUR

T1 - RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

AU - Liu, Jingquan

AU - Tao, Lei

AU - Xu, Jiangtao

AU - Jia, Zhongfan

AU - Boyer, Cyrille

AU - Davis, Thomas P.

PY - 2009/9/10

Y1 - 2009/9/10

N2 - Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS).

AB - Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a 'core-first' methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS).

KW - Biodegradable polymer

KW - RAFT

KW - Star polymer

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DO - 10.1016/j.polymer.2009.07.018

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RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

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Keywords

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