Raman imaging of drug delivery systems

Geoffrey P.S. Smith; Cushla M. McGoverin; Sara J. Fraser; Keith C. Gordon

doi:10.1016/j.addr.2015.01.005

Raman imaging of drug delivery systems

Geoffrey P.S. Smith, Cushla M. McGoverin, Sara J. Fraser, Keith C. Gordon

Research output: Contribution to journal › Review article › peer-review

104 Citations (Scopus)

Abstract

This review article includes an introduction to the principals of Raman spectroscopy, an outline of the experimental systems used for Raman imaging and the associated important considerations and limitations of this method. Common spectral analysis methods are briefly described and examples of interesting published studies which utilised Raman imaging of pharmaceutical and biomedical devices are discussed, along with summary tables of the literature at this point in time.

Original language	English
Pages (from-to)	21-41
Number of pages	21
Journal	Advanced Drug Delivery Reviews
Volume	89
DOIs	https://doi.org/10.1016/j.addr.2015.01.005
Publication status	Published - 15 Jul 2015
Externally published	Yes

Keywords

Chemometrics
Drug delivery
Drug dissolution
Multivariate methods
Polymeric microparticles
Pre-processing
Raman imaging
Solid dispersions

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10.1016/j.addr.2015.01.005Licence: In Copyright

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abstract = "This review article includes an introduction to the principals of Raman spectroscopy, an outline of the experimental systems used for Raman imaging and the associated important considerations and limitations of this method. Common spectral analysis methods are briefly described and examples of interesting published studies which utilised Raman imaging of pharmaceutical and biomedical devices are discussed, along with summary tables of the literature at this point in time.",

keywords = "Chemometrics, Drug delivery, Drug dissolution, Multivariate methods, Polymeric microparticles, Pre-processing, Raman imaging, Solid dispersions",

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AU - McGoverin, Cushla M.

AU - Fraser, Sara J.

AU - Gordon, Keith C.

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Y1 - 2015/7/15

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AB - This review article includes an introduction to the principals of Raman spectroscopy, an outline of the experimental systems used for Raman imaging and the associated important considerations and limitations of this method. Common spectral analysis methods are briefly described and examples of interesting published studies which utilised Raman imaging of pharmaceutical and biomedical devices are discussed, along with summary tables of the literature at this point in time.

KW - Chemometrics

KW - Drug delivery

KW - Drug dissolution

KW - Multivariate methods

KW - Polymeric microparticles

KW - Pre-processing

KW - Raman imaging

KW - Solid dispersions

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DO - 10.1016/j.addr.2015.01.005

M3 - Review article

SN - 0169-409X

VL - 89

SP - 21

EP - 41

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Raman imaging of drug delivery systems

Abstract

Keywords

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