Randomised controlled trials in ophthalmology

In his engaging 2020 editorial in Clinical and Experimental Ophthalmology – Register your interest – Gillies outlined the high merits of observational outcomes registries in ophthalmology, highlighting three articles in the same issue that used this approach to generate ‘information that is useful for the management of our patients’. The current issue of the journal includes three articles that use the other major clinical investigation, the randomised controlled trial (RCT). In these prospective studies, subjects are assigned randomly to groups of interventions, which may include placebo, to measure the effectiveness and safety of a new treatment...