Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements

Megan Kendall, Marijka Batterham, Damien Callahan, Daniel Jardine, Paul Prenzler, Kevin Robards, Danielle Ryan

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Olive leaf supplement was characterised by HPLC and administered to healthy young adults over 28 d (three tablets or equivalent liquid dose per day), or in a single bolus dose of three tablets (or liquid equivalent). Oleuropein was the major biophenol in the extracts. There are no data on the excretion of urinary end-products of the metabolism of the olive leaf biophenols. Following both chronic and acute ingestion neither oleuropein, nor its hydrolysis product, hydroxytyrosol, were detected in urine samples. However, glucuronic acid conjugates, derived from oleuropein aglycone were detected in all urine samples up to 6 h following acute ingestion. The data suggest that oleuropein is bioavailable, which is a necessary pre-condition for bioactivity.

    Original languageEnglish
    Pages (from-to)651-659
    Number of pages9
    JournalFood Chemistry
    Volume130
    Issue number3
    DOIs
    Publication statusPublished - 1 Feb 2012

    Keywords

    • Adults
    • Excretion
    • Healthy
    • Oleuropein
    • Urine

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