Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial)

Rajiv Ananthakrishna, Sau L. Lee, Jonathon Foote, Benedetta C. Sallustio, Giulia Binda, Arduino A. Mangoni, Richard Woodman, Christopher Semsarian, John D. Horowitz, Joseph B. Selvanayagam

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The presence and extent of left ventricular hypertrophy (LVH) is a major determinant of symptoms in patients with hypertrophic cardiomyopathy (HCM). There is increasing evidence to suggest that myocardial energetic impairment represents a central mechanism leading to LVH in HCM. There is currently a significant unmet need for disease-modifying therapy that regresses LVH in HCM patients. Perhexiline, a potent carnitine palmitoyl transferase-1 (CPT-1) inhibitor, improves myocardial energetics in HCM, and has the potential to reduce LVH in HCM. Objective: The primary objective is to evaluate the effects of perhexiline treatment on the extent of LVH, in symptomatic HCM patients with at least moderate LVH. Methods/Design: RESOLVE-HCM is a prospective, multicenter double-blind placebo-controlled randomized trial enrolling symptomatic HCM patients with at least moderate LVH. Sixty patients will be randomized to receive either perhexiline or matching placebo. The primary endpoint is change in LVH, assessed utilizing cardiovascular magnetic resonance (CMR) imaging, after 12-months treatment with perhexiline. RESOLVE-HCM will provide novel information on the utility of perhexiline in regression of LVH in symptomatic HCM patients. A positive result would lead to the design of a Phase 3 clinical trial addressing long-term effects of perhexiline on risk of heart failure and mortality in HCM patients.

Original languageEnglish
Pages (from-to)101-113
Number of pages13
JournalAmerican Heart Journal
Volume240
DOIs
Publication statusPublished - Oct 2021

Keywords

  • left ventricular hypertrophy (LVH)
  • hypertrophic cardiomyopathy (HCM)
  • disease-modifying therapy
  • Perhexiline
  • myocardial energetics
  • RESOLVE-HCM

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