Rapid aqueous 'click chemistry' using Cu(I)-loaded dendrimers as macromolecular catalysts

Eli Moore, Steven McInnes, Andrew Vogt, Nicolas Voelcker

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)


    Here, we investigate the catalytic activity of various copper (Cu)-loaded poly(amido amine) (PAMAM) dendrimers towards the Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC). Reactivity is tested on a model reaction between azido propanol and propargyl alcohol in aqueous solution. We observe significantly faster conversion using PAMAM dendrimers as macromolecular Cu(I) ligands compared to traditional small molecular ligand systems, and demonstrate that the macromolecular catalyst can be removed by ultrafiltration.

    Original languageEnglish
    Pages (from-to)2327-2329
    Number of pages3
    JournalTetrahedron Letters
    Issue number18
    Publication statusPublished - 4 May 2011


    • Catalyst
    • Click chemistry
    • Dendrimer
    • PAMAM


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