Rapid translation of COVID-19 preprint data into critical care practice

Aidan J.C. Burrell, Ary Serpa Neto, Tony Trapani, Tessa Broadley, Craig French, Andrew A. Udy, SPRINT-SARI Australia Investigators, Allen Cheng, David Brewster, Lewis Campbell, Matthew Anstey, Paul Secombe, Shailesh Bihari

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The global coronavirus disease (COVID-19) pandemic has seen a significant increase in the use of preprint services to enable the widespread dissemination of research findings (1). However,whether such facilities influence practice change is currently unknown. Here, we describe the impact of the preprint release and eventual publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (2) on corticosteroid use in clinical practice in Australian ICUs. The RECOVERY trial tested the efficacy of dexamethasone (6 mg by mouth or intravenously for upto 10 d) in hospitalized patients with clinically suspected or confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection and demonstrated a reduction in 28-day mortality, particularly in those receiving either mechanical ventilation or oxygen. Before these results, the Australian and New Zealand Intensive Care Society COVID-19 guidelines recommended against the routine use of corticosteroids.
Original languageEnglish
Pages (from-to)368-371
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Issue number3
Publication statusPublished - 1 Feb 2021


  • COVID-19
  • preprint services
  • research findings
  • preprint data
  • Critical Care Medicine


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