@article{4fa649a494f141d784234f4afcc2e416,
title = "Rapid translation of COVID-19 preprint data into critical care practice",
abstract = "The global coronavirus disease (COVID-19) pandemic has seen a significant increase in the use of preprint services to enable the widespread dissemination of research findings (1). However,whether such facilities influence practice change is currently unknown. Here, we describe the impact of the preprint release and eventual publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (2) on corticosteroid use in clinical practice in Australian ICUs. The RECOVERY trial tested the efficacy of dexamethasone (6 mg by mouth or intravenously for upto 10 d) in hospitalized patients with clinically suspected or confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection and demonstrated a reduction in 28-day mortality, particularly in those receiving either mechanical ventilation or oxygen. Before these results, the Australian and New Zealand Intensive Care Society COVID-19 guidelines recommended against the routine use of corticosteroids.",
keywords = "COVID-19, preprint services, research findings, preprint data, Critical Care Medicine",
author = "Burrell, {Aidan J.C.} and Neto, {Ary Serpa} and Tony Trapani and Tessa Broadley and Craig French and Udy, {Andrew A.} and {SPRINT-SARI Australia Investigators} and Adam Visser and Adrian Mattke and Adrian Regli and Alan Rashid and Alexis Tabah and Alison Walker and Allen Cheng and Amanda Corley and Anil Ramnani and Anne Leditschke and Anthony Eidan and Bart DeKeulenaer and Baumik Mevavala and Ben Mulholland and Benjamin Reddi and Brent Richards and Cameron Knott and Cara Moore and Carmel Delzoppo and Catherine Boschert and Catherine Tacon and Claire Corrigan and Danielle Austin and David Brewster and David Cooper and David Crosbie and David Hawkins and Edda Jessen and Eduardo Martinez and Edward Fysh and Edward Litton and Felix Oberender and Forbes McGain and Gavin Salt and Glenn Eastwood and Gopal Taori and Hannah Thompson and Hayden White and Hergen Buscher and Ian Seppelt and Ifrah Khan and Janelle Young and Jayshree Lavana and Jeremy Cohen and Jessica Lugsdin and Jill Garlick and Jim Buttery and John Botha and John Santamaria and Jonathan Barrett and Kasha Singh and Kevin Laupland and Khaled El-Khawas and Kristine Estensen and Kush Deshpande and Kyle White and Leigh Fitzpatrick and Lewis Campbell and Mahesh Ramanan and Manoj Saxena and Marie Draper and Marion Kainer and Mark Kol and Mark Page and Mark Plummer and Martin Sterba and Matthew Anstey and Matthew Brain and Matthew Maiden and Myrene Kilminster and Naomi Hammond and Neeraj Bhadange and Nicole Humphreys and Paras Jain and Paul Azzi and Paul Secombe and Paula Lister and Peter Chan and Peter McCanny and Phillip Britton and Pierre Janin and Rashmi Runiyar and Ravi Krishnamurthy and Ravikiran Sonawane and Ravindranath Tiruvoipati and Rebecca Jessup and Richard Totaro and Rinaldo Bellomo and Ritesh Sanghavi and Samantha Bates and Sandra Peake and Shailesh Bihari and Shane George and Sharon Waterson and Simon Erickson and Steve Webb and Subhash Arora and Subodh Ganu and Thomas Rozen and Toni McKenna and Umesh Kadam and Vineet Nayyar and Choy, {Wei Han} and Wisam Albassam",
year = "2021",
month = feb,
day = "1",
doi = "10.1164/rccm.202009-3661LE",
language = "English",
volume = "203",
pages = "368--371",
journal = "American journal of respiratory and critical care medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",
}