RCH-ACV: A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8

I. Jack; R. Seshadri; M. Garson; P. Michael; D. Callen; H. Zola; A. Morley

doi:10.1016/0165-4608(86)90055-5

RCH-ACV: A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8

I. Jack, R. Seshadri, M. Garson, P. Michael, D. Callen, H. Zola, A. Morley

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.

Original language	English
Pages (from-to)	261-269
Number of pages	9
Journal	Cancer Genetics and Cytogenetics
Volume	19
Issue number	3-4
DOIs	https://doi.org/10.1016/0165-4608(86)90055-5
Publication status	Published - 15 Jan 1986

Access to Document

10.1016/0165-4608(86)90055-5Licence: In Copyright

Cite this

@article{3495a93c7f1648a7a5f45606a2af2b1c,

title = "RCH-ACV: A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8",

abstract = "A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.",

author = "I. Jack and R. Seshadri and M. Garson and P. Michael and D. Callen and H. Zola and A. Morley",

year = "1986",

month = jan,

day = "15",

doi = "10.1016/0165-4608(86)90055-5",

language = "English",

volume = "19",

pages = "261--269",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "3-4",

}

TY - JOUR

T1 - RCH-ACV

T2 - A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8

AU - Jack, I.

AU - Seshadri, R.

AU - Garson, M.

AU - Michael, P.

AU - Callen, D.

AU - Zola, H.

AU - Morley, A.

PY - 1986/1/15

Y1 - 1986/1/15

N2 - A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.

AB - A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.

UR - http://www.scopus.com/inward/record.url?scp=0022644777&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(86)90055-5

DO - 10.1016/0165-4608(86)90055-5

M3 - Article

C2 - 3455845

AN - SCOPUS:0022644777

SN - 0165-4608

VL - 19

SP - 261

EP - 269

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 3-4

ER -

RCH-ACV: A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8

Abstract

Access to Document

Other files and links

Fingerprint

Cite this