RCH-ACV: A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8

I. Jack, R. Seshadri, M. Garson, P. Michael, D. Callen, H. Zola, A. Morley

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.

    Original languageEnglish
    Pages (from-to)261-269
    Number of pages9
    JournalCancer Genetics and Cytogenetics
    Volume19
    Issue number3-4
    DOIs
    Publication statusPublished - 15 Jan 1986

    Fingerprint Dive into the research topics of 'RCH-ACV: A lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8'. Together they form a unique fingerprint.

    Cite this