Re: Prevalence of MRI Lesions in Men Responding to a GP-led Invitation for a Prostate Health Check: A Prospective Cohort Study

Michael O'Callaghan, Norma Bulamu, Kirsten Gormly, Alex Jay

Research output: Contribution to journalComment/debate

Abstract

This prospective screening study reported on the prevalence of prostate cancer among participants with positive screening magnetic resonance imaging (MRI). Eight general practices referring to a teaching hospital in London invited 2096 men to participate. The men were aged 50–75 yr, similar to current criteria for prostate-specific antigen (PSA) screening. A total of 457 men responded, of whom 309 were recruited.

Participants had a PSA blood test and limited screening MRI (sMRI), and PSA density (PSAD) was calculated. Men with positive sMRI or PSAD >0.12 ng/ml2 were referred for further assessment according to standard National Health Service protocols. Of those who completed screening, 48/303 (16%) had positive sMRI findings and a further 16/303 (5%) had a positive PSAD result. Of these cases, 32 had a positive cancer diagnosis, of which only three were insignificant. Importantly, more than half of those with a diagnosis of cancer had PSA <3 ng/ml, the current threshold for further investigations in PSA screening guidelines.
Original languageEnglish
Pages (from-to)395
Number of pages1
JournalEuropean Urology
Volume85
Issue number4
Early online date25 Nov 2023
DOIs
Publication statusPublished - Apr 2024

Keywords

  • Prostate cancer
  • Health checks
  • MRI scan
  • MRI Lesions

Fingerprint

Dive into the research topics of 'Re: Prevalence of MRI Lesions in Men Responding to a GP-led Invitation for a Prostate Health Check: A Prospective Cohort Study'. Together they form a unique fingerprint.

Cite this