Abstract
This prospective screening study reported on the prevalence of prostate cancer among participants with positive screening magnetic resonance imaging (MRI). Eight general practices referring to a teaching hospital in London invited 2096 men to participate. The men were aged 50–75 yr, similar to current criteria for prostate-specific antigen (PSA) screening. A total of 457 men responded, of whom 309 were recruited.
Participants had a PSA blood test and limited screening MRI (sMRI), and PSA density (PSAD) was calculated. Men with positive sMRI or PSAD >0.12 ng/ml2 were referred for further assessment according to standard National Health Service protocols. Of those who completed screening, 48/303 (16%) had positive sMRI findings and a further 16/303 (5%) had a positive PSAD result. Of these cases, 32 had a positive cancer diagnosis, of which only three were insignificant. Importantly, more than half of those with a diagnosis of cancer had PSA <3 ng/ml, the current threshold for further investigations in PSA screening guidelines.
Participants had a PSA blood test and limited screening MRI (sMRI), and PSA density (PSAD) was calculated. Men with positive sMRI or PSAD >0.12 ng/ml2 were referred for further assessment according to standard National Health Service protocols. Of those who completed screening, 48/303 (16%) had positive sMRI findings and a further 16/303 (5%) had a positive PSAD result. Of these cases, 32 had a positive cancer diagnosis, of which only three were insignificant. Importantly, more than half of those with a diagnosis of cancer had PSA <3 ng/ml, the current threshold for further investigations in PSA screening guidelines.
| Original language | English |
|---|---|
| Pages (from-to) | 395 |
| Number of pages | 1 |
| Journal | European Urology |
| Volume | 85 |
| Issue number | 4 |
| Early online date | 25 Nov 2023 |
| DOIs |
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| Publication status | Published - Apr 2024 |
Keywords
- Prostate cancer
- Health checks
- MRI scan
- MRI Lesions