Reagents and methods for diversification of DNA

David Catcheside (Inventor)

    Research output: Patent

    3 Downloads (Pure)


    The present invention provides methods and compositions for diversification of heterologous DNA sequences in vivo. The present invention employs a recombination hotspot functionally coupled to the heterologous DNA. The process of recombination generates new versions of the foreign sequences by recombining their differences in new combinations. Errors in recombination generate additional sequence diversity.
    Original languageEnglish
    Patent numberWO1999027072A1
    Filing date24/11/97
    Publication statusPublished - 3 Jun 1999


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