Abstract
The present invention provides methods and compositions for diversification of heterologous DNA sequences in vivo. The present invention employs a recombination hotspot functionally coupled to the heterologous DNA. The process of recombination generates new versions of the foreign sequences by recombining their differences in new combinations. Errors in recombination generate additional sequence diversity.
| Original language | English |
|---|---|
| Patent number | WO1999027072A1 |
| Filing date | 24/11/97 |
| Publication status | Published - 3 Jun 1999 |