Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch

Joao M. Braz, Alex Etlin, Dina Juarez-Salinas, Ida J. Llewellyn-Smith, Allan I. Basbaum

    Research output: Chapter in Book/Report/Conference proceedingChapter

    3 Citations (Scopus)

    Abstract

    Cell transplantation offers an attractive alternative to pharmacotherapy for the management of a host of clinical conditions. Most importantly, the transplanted cells provide a continuous, local delivery of therapeutic compounds, which avoids many of the adverse side effects associated with systemically administered drugs. Here, we describe the broad therapeutic utility of transplanting precursors of cortical inhibitory interneurons derived from the embryonic medial ganglionic eminence (MGE), in a variety of chronic pain and itch models in the mouse. Despite the cortical environment in which the MGE cells normally develop, these cells survive transplantation and will even integrate into the circuitry of an adult host spinal cord. When transplanted into the spinal cord, the cells significantly reduce the hyperexcitability that characterizes both chronic neuropathic pain and itch conditions. This MGE cell-based strategy differs considerably from traditional pharmacological treatments as the approach is potentially disease modifying (i.e., the therapy targets the underlying etiology of the pain and itch pathophysiology).

    Original languageEnglish
    Title of host publicationProgress in Brain Research
    PublisherElsevier B.V.
    Chapter4
    Pages87-105
    Number of pages19
    Volume231
    ISBN (Print)0079-6123
    DOIs
    Publication statusPublished - 1 Jan 2017

    Publication series

    NameProgress in Brain Research
    Volume231
    ISSN (Print)0079-6123
    ISSN (Electronic)1875-7855

    Keywords

    • Cell transplant
    • Dorsal horn
    • GABA
    • Itch
    • Medial ganglionic eminence
    • Pain
    • Spinal cord

    Fingerprint Dive into the research topics of 'Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch'. Together they form a unique fingerprint.

  • Cite this

    Braz, J. M., Etlin, A., Juarez-Salinas, D., Llewellyn-Smith, I. J., & Basbaum, A. I. (2017). Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch. In Progress in Brain Research (Vol. 231, pp. 87-105). (Progress in Brain Research; Vol. 231). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2016.10.001