TY - JOUR
T1 - Recent advances in solventless organic reactions
T2 - Towards benign synthesis with remarkable versatility
AU - Cave, Gareth W.V.
AU - Raston, Colin L.
AU - Scott, Janet L.
PY - 2001/11/7
Y1 - 2001/11/7
N2 - A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.
AB - A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.
UR - http://www.scopus.com/inward/record.url?scp=0035823954&partnerID=8YFLogxK
U2 - 10.1039/b106677n
DO - 10.1039/b106677n
M3 - Article
C2 - 12240095
AN - SCOPUS:0035823954
SN - 1359-7345
VL - 21
SP - 2159
EP - 2169
JO - Chemical Communications
JF - Chemical Communications
ER -