Recent advances in solventless organic reactions: Towards benign synthesis with remarkable versatility

Gareth W.V. Cave, Colin L. Raston, Janet L. Scott

Research output: Contribution to journalArticle

539 Citations (Scopus)

Abstract

A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.

Original languageEnglish
Pages (from-to)2159-2169
Number of pages11
JournalChemical Communications
Volume21
DOIs
Publication statusPublished - 7 Nov 2001
Externally publishedYes

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