Recent advances in solventless organic reactions: Towards benign synthesis with remarkable versatility

Gareth W.V. Cave; Colin L. Raston; Janet L. Scott

doi:10.1039/b106677n

Recent advances in solventless organic reactions: Towards benign synthesis with remarkable versatility

Gareth W.V. Cave, Colin L. Raston, Janet L. Scott

Research output: Contribution to journal › Article › peer-review

620 Citations (Scopus)

Abstract

A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.

Original language	English
Pages (from-to)	2159-2169
Number of pages	11
Journal	Chemical Communications
Volume	21
DOIs	https://doi.org/10.1039/b106677n
Publication status	Published - 7 Nov 2001
Externally published	Yes

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Recent advances in solventless organic reactions: Towards benign synthesis with remarkable versatility

Abstract

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