Recent advances refining galactooligosaccharide production from lactose

Aaron Gosling; Geoff Stevens; Andrew Barber; Sandra Kentish; Sally Gras

doi:10.1016/j.foodchem.2009.12.063

Recent advances refining galactooligosaccharide production from lactose

Aaron Gosling, Geoff Stevens, Andrew Barber, Sandra Kentish, Sally Gras

Research output: Contribution to journal › Review article › peer-review

252 Citations (Scopus)

Abstract

The production of prebiotic galactooligosaccharides (GOS) by the β-galactosidase catalysed conversion of lactose has become commercially important. Yet it remains a challenge to sufficiently understand the structure and activity of β-galactosidase, to increase the efficiency of transgalactosylation and GOS production and to improve the quality of GOS products in a rational way. This review covers the broad but related aspects of GOS synthesis including: the structure and reaction mechanism of β-galactosidase, factors effecting yield and productivity of GOS synthesis systems, the structure of GOS products, models for the kinetics of GOS synthesis and reactor configurations for GOS synthesis. It aims to couple recent discoveries with established knowledge to enhance understanding of the complex biochemistry of GOS synthesis.

Original language	English
Pages (from-to)	307-318
Number of pages	12
Journal	Food Chemistry
Volume	121
Issue number	2
DOIs	https://doi.org/10.1016/j.foodchem.2009.12.063
Publication status	Published - 15 Jul 2010

Keywords

β-galactosidase
Galacto-oligosaccharide
Galactooligosaccharide
Galactosyl oligosaccharide
Galactosyl transfer
GOS
Lactose hydrolysis
Prebiotic
Review

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10.1016/j.foodchem.2009.12.063

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title = "Recent advances refining galactooligosaccharide production from lactose",

abstract = "The production of prebiotic galactooligosaccharides (GOS) by the β-galactosidase catalysed conversion of lactose has become commercially important. Yet it remains a challenge to sufficiently understand the structure and activity of β-galactosidase, to increase the efficiency of transgalactosylation and GOS production and to improve the quality of GOS products in a rational way. This review covers the broad but related aspects of GOS synthesis including: the structure and reaction mechanism of β-galactosidase, factors effecting yield and productivity of GOS synthesis systems, the structure of GOS products, models for the kinetics of GOS synthesis and reactor configurations for GOS synthesis. It aims to couple recent discoveries with established knowledge to enhance understanding of the complex biochemistry of GOS synthesis.",

keywords = "β-galactosidase, Galacto-oligosaccharide, Galactooligosaccharide, Galactosyl oligosaccharide, Galactosyl transfer, GOS, Lactose hydrolysis, Prebiotic, Review",

author = "Aaron Gosling and Geoff Stevens and Andrew Barber and Sandra Kentish and Sally Gras",

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AU - Gosling, Aaron

AU - Stevens, Geoff

AU - Barber, Andrew

AU - Kentish, Sandra

AU - Gras, Sally

PY - 2010/7/15

Y1 - 2010/7/15

N2 - The production of prebiotic galactooligosaccharides (GOS) by the β-galactosidase catalysed conversion of lactose has become commercially important. Yet it remains a challenge to sufficiently understand the structure and activity of β-galactosidase, to increase the efficiency of transgalactosylation and GOS production and to improve the quality of GOS products in a rational way. This review covers the broad but related aspects of GOS synthesis including: the structure and reaction mechanism of β-galactosidase, factors effecting yield and productivity of GOS synthesis systems, the structure of GOS products, models for the kinetics of GOS synthesis and reactor configurations for GOS synthesis. It aims to couple recent discoveries with established knowledge to enhance understanding of the complex biochemistry of GOS synthesis.

AB - The production of prebiotic galactooligosaccharides (GOS) by the β-galactosidase catalysed conversion of lactose has become commercially important. Yet it remains a challenge to sufficiently understand the structure and activity of β-galactosidase, to increase the efficiency of transgalactosylation and GOS production and to improve the quality of GOS products in a rational way. This review covers the broad but related aspects of GOS synthesis including: the structure and reaction mechanism of β-galactosidase, factors effecting yield and productivity of GOS synthesis systems, the structure of GOS products, models for the kinetics of GOS synthesis and reactor configurations for GOS synthesis. It aims to couple recent discoveries with established knowledge to enhance understanding of the complex biochemistry of GOS synthesis.

KW - β-galactosidase

KW - Galacto-oligosaccharide

KW - Galactooligosaccharide

KW - Galactosyl oligosaccharide

KW - Galactosyl transfer

KW - GOS

KW - Lactose hydrolysis

KW - Prebiotic

KW - Review

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U2 - 10.1016/j.foodchem.2009.12.063

DO - 10.1016/j.foodchem.2009.12.063

M3 - Review article

SN - 0308-8146

VL - 121

SP - 307

EP - 318

JO - Food Chemistry

JF - Food Chemistry

IS - 2

ER -

Recent advances refining galactooligosaccharide production from lactose

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