Recent advances refining galactooligosaccharide production from lactose

Aaron Gosling, Geoff Stevens, Andrew Barber, Sandra Kentish, Sally Gras

    Research output: Contribution to journalReview articlepeer-review

    268 Citations (Scopus)


    The production of prebiotic galactooligosaccharides (GOS) by the β-galactosidase catalysed conversion of lactose has become commercially important. Yet it remains a challenge to sufficiently understand the structure and activity of β-galactosidase, to increase the efficiency of transgalactosylation and GOS production and to improve the quality of GOS products in a rational way. This review covers the broad but related aspects of GOS synthesis including: the structure and reaction mechanism of β-galactosidase, factors effecting yield and productivity of GOS synthesis systems, the structure of GOS products, models for the kinetics of GOS synthesis and reactor configurations for GOS synthesis. It aims to couple recent discoveries with established knowledge to enhance understanding of the complex biochemistry of GOS synthesis.

    Original languageEnglish
    Pages (from-to)307-318
    Number of pages12
    JournalFood Chemistry
    Issue number2
    Publication statusPublished - 15 Jul 2010


    • β-galactosidase
    • Galacto-oligosaccharide
    • Galactooligosaccharide
    • Galactosyl oligosaccharide
    • Galactosyl transfer
    • GOS
    • Lactose hydrolysis
    • Prebiotic
    • Review


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