Recent Progress in Metal Catalyzed Direct Carboxylation of Aryl Halides and Pseudo Halides Employing CO2: Opportunities for 11C Radiochemistry

Muneer Ahamed, Joost Verbeek, Uta Funke, Joan Lecina, Alfons Verbruggen, Guy Bormans

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Carbon dioxide (CO2) as a synthon in organic transformations is very useful, especially when combined with transition metal catalysts. CO2 insertion on carbon(Aryl)-metal is are an elegant route to construct carbon–carbon bonds. A limited number of reports have been published to date on the direct conversion of aryl halides (or pseudo halides) to aryl carboxylic acids using transition metal catalysts. These reactions place great demand on the choice of catalyst, starting material, and reducing agent. However, these approaches could be of interest for the synthesis of a wide range of biologically active small molecules. Such transformations have already been applied for the synthesis of radiolabeled compounds for imaging with positron emission tomography (PET) using cyclotron produced [11C]CO2 and may be applicable to the production of a diverse range of PET tracers.

    Original languageEnglish
    Pages (from-to)3692-3700
    Number of pages9
    JournalChemCatChem
    Volume8
    Issue number24
    DOIs
    Publication statusPublished - 2016

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