Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motorneurons

Yee Lian Chew, Denise S. Walker, Emma K. Towlson, Petra E. Vértes, Gang Yan, Albert László Barabási, William R. Schafer

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
1 Downloads (Pure)

Abstract

Lesioning studies have provided important insight into the functions of brain regions in humans and other animals. In the nematode Caenorhabditis elegans, with a small nervous system of 302 identified neurons, it is possible to generate lesions with single cell resolution and infer the roles of individual neurons in behaviour. Here we present a dataset of ∼300 video recordings representing the locomotor behaviour of animals carrying single-cell ablations of 5 different motorneurons. Each file includes a raw video of approximately 27,000 frames; each frame has also been segmented to yield the position, contour, and body curvature of the tracked animal. These recordings can be further analysed using publicly-available software to extract features relevant to behavioural phenotypes. This dataset therefore represents a useful resource for probing the neural basis of behaviour in C. elegans, a resource we hope to augment in the future with ablation recordings for additional neurons.

Original languageEnglish
Article number170156
Number of pages7
JournalScientific Data
Volume4
DOIs
Publication statusPublished - 19 Oct 2017
Externally publishedYes

Keywords

  • Caenorhabditis elegans
  • locomotor behaviours
  • ablation
  • motorneurons
  • lesioning studies
  • brain behaviour

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