Recurrent and refractory hemophagocytic lymphohistiocytosis in an elderly. Role of immune aberration due to myeloid gene mutation

Suthanthira Kannan Ramamoorthy, Tina Noutsos, David Wei, Alexandra Yasmin Laidman, Ferenc Szabo

Research output: Contribution to journalArticlepeer-review

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper-inflammatory disease induced by aberrant immune activation and subsequent proliferation of macrophages, histiocytes and T-helper cells. In this abstract we present a case of HLH, which relapsed twice despite ongoing treatment, and we hypothesize on possible causes and mechanisms...
Original languageEnglish
Pages (from-to)24-26
Number of pages3
JournalBlood
Volume136
Issue numberSupplement 1
DOIs
Publication statusPublished - 5 Nov 2020
Externally publishedYes

Keywords

  • Hemophagocytic Lymphohistiocytosis
  • hyper-inflammatory disease
  • aberrant immune activation
  • Myeloid Gene Mutation

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