Recurrent and refractory hemophagocytic lymphohistiocytosis in an elderly. Role of immune aberration due to myeloid gene mutation

Suthanthira Kannan Ramamoorthy; Tina Noutsos; David Wei; Alexandra Yasmin Laidman; Ferenc Szabo

doi:10.1182/blood-2020-133776

Recurrent and refractory hemophagocytic lymphohistiocytosis in an elderly. Role of immune aberration due to myeloid gene mutation

Suthanthira Kannan Ramamoorthy, Tina Noutsos, David Wei, Alexandra Yasmin Laidman, Ferenc Szabo

Research output: Contribution to journal › Article › peer-review

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper-inflammatory disease induced by aberrant immune activation and subsequent proliferation of macrophages, histiocytes and T-helper cells. In this abstract we present a case of HLH, which relapsed twice despite ongoing treatment, and we hypothesize on possible causes and mechanisms...

Original language	English
Pages (from-to)	24-26
Number of pages	3
Journal	Blood
Volume	136
Issue number	Supplement 1
DOIs	https://doi.org/10.1182/blood-2020-133776
Publication status	Published - 5 Nov 2020
Externally published	Yes

Keywords

Hemophagocytic Lymphohistiocytosis
hyper-inflammatory disease
aberrant immune activation
Myeloid Gene Mutation

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abstract = "Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper-inflammatory disease induced by aberrant immune activation and subsequent proliferation of macrophages, histiocytes and T-helper cells. In this abstract we present a case of HLH, which relapsed twice despite ongoing treatment, and we hypothesize on possible causes and mechanisms...",

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AU - Ramamoorthy, Suthanthira Kannan

AU - Noutsos, Tina

AU - Wei, David

AU - Laidman, Alexandra Yasmin

AU - Szabo, Ferenc

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AB - Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper-inflammatory disease induced by aberrant immune activation and subsequent proliferation of macrophages, histiocytes and T-helper cells. In this abstract we present a case of HLH, which relapsed twice despite ongoing treatment, and we hypothesize on possible causes and mechanisms...

KW - Hemophagocytic Lymphohistiocytosis

KW - hyper-inflammatory disease

KW - aberrant immune activation

KW - Myeloid Gene Mutation

U2 - 10.1182/blood-2020-133776

DO - 10.1182/blood-2020-133776

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SN - 0006-4971

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