Red Blood Cell Distribution Width (RDW) Correlates to the Anatomical Location of Colorectal Cancer. Implications for Clinical Use

Alessandro Fancellu, Angelo Zinellu, Arduino Aleksander Mangoni, Anastasia Popova, Francesca Galotti, Claudio Francesco Feo, Federico Attene, Antonio Cossu, Giuseppe Palmieri, Panagiotis Paliogiannis

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The pathological, clinical, and therapeutic features of colorectal cancer (CRC) depend on its anatomical localization. We investigated possible associations between the red blood cell distribution width (RDW) and CRC localization. Methods: Two-hundred eighty-eight consecutive patients with CRC were retrospectively studied. Demographic, clinical, pathological and laboratory data were retrieved from clinical records and reports. Results: Median RDW values were significantly higher in patients with right-sided CRC when compared to those with CRC in other localizations (16.2, IQR: 14.5–20.0 vs 13.8, IQR: 13.0–16.1, p < 0.0001). Anisocytosis was statistically associated to haemoglobin (Hb), mean haemoglobin concentration (MHC), and mean corpuscular volume (MCV) values in all the patient groups examined. A cut-off value of 14.3% was associated with right-sided localization with sensitivity and specificity of 76.3% and 64.2%, respectively (AUC 0.71). Conclusion: Median RDW values were significantly higher in right-sided CRC when compared to other tumour locations, and may represent an additional marker for differential diagnosis.

Original languageEnglish
Number of pages6
JournalJournal of Gastrointestinal Cancer
Early online date12 Jan 2021
DOIs
Publication statusE-pub ahead of print - 12 Jan 2021

Keywords

  • Anisocytosis
  • Colorectal cancer
  • Red blood cell distribution width
  • Tumour location

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