Red cell autoimmunization and alloimmunization in myelodysplastic syndromes: prevalence, characteristic and significance

Rakchha Chhetri, Li Yan A. Wee, Romi Sinha, Monika Kutyna, Anh Pham, Helen Stathopoulos, Lakshmi Nath, Shriram V. Nath, Nicholas Wickham, Timothy P. Hughes, Deepak Singhal, David Roxby, Devendra Hiwase

    Research output: Contribution to journalLetterpeer-review

    5 Citations (Scopus)

    Abstract

    The association between red blood cell (RBC) auto-and alloantibodies has been reported, primarily in the context of warm autoimmune hemolytic anemia (AIHA). Forty to fifty percent of AIHA patients also have RBC-alloantibodies,21 usually as a result of previous RBC transfusions, with autoantibodies playing very little role in their development. Conversely, the occurrence of autoantibody in alloimmunized patients is less well recognized and has primarily been reported in sickle cell disease (SCD) and thalassemia.63 Importantly, autoimmunization can lead to severe AIHA754 and make it difficult to find compatible blood. However, incidence, risk factors, and significance of RBC autoimmunization has not been reported in myelodysplastic syndrome (MDS) patients...
    Original languageEnglish
    Pages (from-to)E451-E454
    Number of pages4
    JournalHaematologica
    Volume104
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2019

    Keywords

    • Myelodysplastic syndromes
    • autoimmunization

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