Abstract
The lymphocyte colony forming ability of 83 normal healthy individuals aged 17-89 was studied. The total lymphocyte count did not alter with age, but there was a decline in the colony forming ability of cells from people with increasing age (r=-0.68, P <0.001). This age related defect was further investigated in 11 mixing experiments using paired young and old individuals. It was found that the defect in aged individuals was due primarily to a defect in the number and/or proliferative ability of the colony forming cell.
Original language | English |
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Pages (from-to) | 129-134 |
Number of pages | 6 |
Journal | Clinical and Experimental Immunology |
Volume | 49 |
Issue number | 1 |
Publication status | Published - 1982 |
Externally published | Yes |