Reduced lymphocyte colony formation with age

S. J. Alder, A. A. Morley, R. S. Seshadri

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The lymphocyte colony forming ability of 83 normal healthy individuals aged 17-89 was studied. The total lymphocyte count did not alter with age, but there was a decline in the colony forming ability of cells from people with increasing age (r=-0.68, P <0.001). This age related defect was further investigated in 11 mixing experiments using paired young and old individuals. It was found that the defect in aged individuals was due primarily to a defect in the number and/or proliferative ability of the colony forming cell.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalClinical and Experimental Immunology
Issue number1
Publication statusPublished - 1982
Externally publishedYes


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