Abstract
The lymphocyte colony forming ability of 83 normal healthy individuals aged 17-89 was studied. The total lymphocyte count did not alter with age, but there was a decline in the colony forming ability of cells from people with increasing age (r=-0.68, P <0.001). This age related defect was further investigated in 11 mixing experiments using paired young and old individuals. It was found that the defect in aged individuals was due primarily to a defect in the number and/or proliferative ability of the colony forming cell.
| Original language | English |
|---|---|
| Pages (from-to) | 129-134 |
| Number of pages | 6 |
| Journal | Clinical and Experimental Immunology |
| Volume | 49 |
| Issue number | 1 |
| Publication status | Published - 1982 |
| Externally published | Yes |