Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old

Tengyi Cai; Vasiliki Karlaftis; Stephen Hearps; Susan Matthews; Janet Burgess; Paul Monagle; Vera Ignjatovic; The HAPPI Kids study team

doi:10.1007/s00467-020-04612-5

Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old

Tengyi Cai, Vasiliki Karlaftis, Stephen Hearps, Susan Matthews, Janet Burgess, Paul Monagle, Vera Ignjatovic, The HAPPI Kids study team

Research output: Contribution to journal › Article

Abstract

Background: Serum cystatin C (CysC) is a promising biomarker of renal function, which has higher accuracy and sensitivity when compared with creatinine. To better utilise serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC.
Methods: The study subjects consist of healthy term neonates, and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunotubidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs.
Results: A total of 378 samples with equal numbers of males and females were analysed for serum CysC and no outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots.
Conclusions: This study established continuous paediatric reference intervals (RIs) for serum CysC in a healthy term neonates and children. The continuous RIs generated from this study showed the age-based dynamic changes as well as blood group and gender-specific differences for serum CysC.

Original language	English
Pages (from-to)	1959-1966
Number of pages	8
Journal	PEDIATRIC NEPHROLOGY
Volume	35
Issue number	10
Early online date	23 May 2020
DOIs	https://doi.org/10.1007/s00467-020-04612-5
Publication status	Published - Oct 2020
Externally published	Yes

Keywords

Continuous reference intervals
Kidney function
Paediatric
Serum cystatin C

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Cai, T., Karlaftis, V., Hearps, S., Matthews, S., Burgess, J., Monagle, P., Ignjatovic, V., & The HAPPI Kids study team (2020). Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old. PEDIATRIC NEPHROLOGY, 35(10), 1959-1966. https://doi.org/10.1007/s00467-020-04612-5

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abstract = "Background: Serum cystatin C (CysC) is a promising biomarker of renal function, which has higher accuracy and sensitivity when compared with creatinine. To better utilise serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. Methods: The study subjects consist of healthy term neonates, and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunotubidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. Results: A total of 378 samples with equal numbers of males and females were analysed for serum CysC and no outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots. Conclusions: This study established continuous paediatric reference intervals (RIs) for serum CysC in a healthy term neonates and children. The continuous RIs generated from this study showed the age-based dynamic changes as well as blood group and gender-specific differences for serum CysC.",

keywords = "Continuous reference intervals, Kidney function, Paediatric, Serum cystatin C",

author = "Tengyi Cai and Vasiliki Karlaftis and Stephen Hearps and Susan Matthews and Janet Burgess and Paul Monagle and Vera Ignjatovic and {The HAPPI Kids study team}",

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AU - Cai, Tengyi

AU - Karlaftis, Vasiliki

AU - Hearps, Stephen

AU - Matthews, Susan

AU - Burgess, Janet

AU - Monagle, Paul

AU - Ignjatovic, Vera

AU - The HAPPI Kids study team

PY - 2020/10

Y1 - 2020/10

N2 - Background: Serum cystatin C (CysC) is a promising biomarker of renal function, which has higher accuracy and sensitivity when compared with creatinine. To better utilise serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. Methods: The study subjects consist of healthy term neonates, and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunotubidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. Results: A total of 378 samples with equal numbers of males and females were analysed for serum CysC and no outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots. Conclusions: This study established continuous paediatric reference intervals (RIs) for serum CysC in a healthy term neonates and children. The continuous RIs generated from this study showed the age-based dynamic changes as well as blood group and gender-specific differences for serum CysC.

AB - Background: Serum cystatin C (CysC) is a promising biomarker of renal function, which has higher accuracy and sensitivity when compared with creatinine. To better utilise serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. Methods: The study subjects consist of healthy term neonates, and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunotubidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. Results: A total of 378 samples with equal numbers of males and females were analysed for serum CysC and no outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots. Conclusions: This study established continuous paediatric reference intervals (RIs) for serum CysC in a healthy term neonates and children. The continuous RIs generated from this study showed the age-based dynamic changes as well as blood group and gender-specific differences for serum CysC.

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