Regulation of mrna translation by hormone receptors in breast and prostate cancer

Jianling Xie, Eric P. Kusnadi, Luc Furic, Luke A. Selth

Research output: Contribution to journalReview articlepeer-review

Abstract

Breast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis of these malignancies is characterised by dysregulation of sex hormone signalling pathways, mediated by the estrogen receptor-α (ER) in breast cancer and androgen receptor (AR) in prostate cancer. ER and AR are transcription factors whose aberrant function drives oncogenic transcriptional programs to promote cancer growth and progression. While ER/AR are known to stimulate cell growth and survival by modulating gene transcription, emerging findings indicate that their effects in neoplasia are also mediated by dysregulation of protein synthesis (i.e., mRNA translation). This suggests that ER/AR can coordinately perturb both transcriptional and translational programs, resulting in the establishment of proteomes that promote malignancy. In this review, we will discuss relatively understudied aspects of ER and AR activity in regulating protein synthesis as well as the potential of targeting mRNA translation in breast and prostate cancer.

Original languageEnglish
Article number3254
Number of pages26
JournalCancers
Volume13
Issue number13
DOIs
Publication statusPublished - 1 Jul 2021

Keywords

  • Androgen receptor
  • Breast cancer
  • Estrogen receptor
  • MRNA translation
  • MTOR
  • Prostate cancer
  • Protein synthesis

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