Regulation of the cellular actin levels in response to changes in the cell density in ataxia telangiectasia lymphoblastoid cells

Peter J. McKinnon; Leigh A. Burgoyne

doi:10.1016/S0006-291X(84)80285-5

Regulation of the cellular actin levels in response to changes in the cell density in ataxia telangiectasia lymphoblastoid cells

Peter J. McKinnon, Leigh A. Burgoyne

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The level of actin was found to decrease markedly when ataxia telangiectasia lymphoblastoid cells were stepped from low to high density culture conditions. Additionally, as the actin levels decreased the levels of a protein species of 37K daltons increased by orders of magnitude. Partial proteolytic digestion of the 37K protein and actin revealed that the primary structures of these proteins were not related. This phenomena was observed in three out of four ataxia telangiectasia lymphoblastoid cell lines but not in lymphoblastoid cells derived from normal individuals.

Original language	English
Pages (from-to)	561-566
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(84)80285-5
Publication status	Published - 15 Mar 1984

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abstract = "The level of actin was found to decrease markedly when ataxia telangiectasia lymphoblastoid cells were stepped from low to high density culture conditions. Additionally, as the actin levels decreased the levels of a protein species of 37K daltons increased by orders of magnitude. Partial proteolytic digestion of the 37K protein and actin revealed that the primary structures of these proteins were not related. This phenomena was observed in three out of four ataxia telangiectasia lymphoblastoid cell lines but not in lymphoblastoid cells derived from normal individuals.",

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AU - Burgoyne, Leigh A.

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AB - The level of actin was found to decrease markedly when ataxia telangiectasia lymphoblastoid cells were stepped from low to high density culture conditions. Additionally, as the actin levels decreased the levels of a protein species of 37K daltons increased by orders of magnitude. Partial proteolytic digestion of the 37K protein and actin revealed that the primary structures of these proteins were not related. This phenomena was observed in three out of four ataxia telangiectasia lymphoblastoid cell lines but not in lymphoblastoid cells derived from normal individuals.

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Regulation of the cellular actin levels in response to changes in the cell density in ataxia telangiectasia lymphoblastoid cells

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