Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Jessica M. Logan; Carmela Martini; Alexandra Sorvina; Ian R.D. Johnson; Robert D. Brooks; Maria C. Caruso; Chelsea Huzzell; Courtney R. Moore; Litsa Karageorgos; Lisa M. Butler; Prerna Tewari; Sarita Prabhakaran; Shane M. Hickey; Sonja Klebe; Hemamali Samaratunga; Brett Delahunt; Kim Moretti; John J. O’Leary; Douglas A. Brooks; Ben S.Y. Ung

doi:10.1038/s41597-024-03696-0

Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Jessica M. Logan, Carmela Martini, Alexandra Sorvina, Ian R.D. Johnson, Robert D. Brooks, Maria C. Caruso, Chelsea Huzzell, Courtney R. Moore, Litsa Karageorgos, Lisa M. Butler, Prerna Tewari, Sarita Prabhakaran, Shane M. Hickey, Sonja Klebe, Hemamali Samaratunga, Brett Delahunt, Kim Moretti, John J. O’Leary, Douglas A. Brooks, Ben S.Y. Ung

College of Medicine and Public Health

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Abstract

The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to interpret and introduce inter-observer variability. Here, we present a digital pathology atlas and online resource of prostate cancer tissue micrographs for both H&E and the reinterpretation of samples using a novel set of three biomarkers as an interactive tool, where clinicians and scientists can explore high resolution histopathology from various case studies. The digital pathology prostate cancer atlas when used in conjunction with the biomarkers, will assist pathologists to accurately grade prostate cancer tissue samples.

Original language	English
Article number	852
Number of pages	10
Journal	Scientific Data
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41597-024-03696-0
Publication status	Published - Dec 2024

Keywords

prostate cancer
Histopathology
Appl1
Sortilin
Syndecan-1
biomarkers
Haematoxylin
H&E stains

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Published versionFinal published version, 2.98 MBLicence: CC BY

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Logan, J. M., Martini, C., Sorvina, A., Johnson, I. R. D., Brooks, R. D., Caruso, M. C., Huzzell, C., Moore, C. R., Karageorgos, L., Butler, L. M., Tewari, P., Prabhakaran, S., Hickey, S. M., Klebe, S., Samaratunga, H., Delahunt, B., Moretti, K., O’Leary, J. J., Brooks, D. A., & Ung, B. S. Y. (2024). Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers. Scientific Data, 11(1), Article 852. https://doi.org/10.1038/s41597-024-03696-0

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abstract = "The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to interpret and introduce inter-observer variability. Here, we present a digital pathology atlas and online resource of prostate cancer tissue micrographs for both H&E and the reinterpretation of samples using a novel set of three biomarkers as an interactive tool, where clinicians and scientists can explore high resolution histopathology from various case studies. The digital pathology prostate cancer atlas when used in conjunction with the biomarkers, will assist pathologists to accurately grade prostate cancer tissue samples.",

keywords = "prostate cancer, Histopathology, Appl1, Sortilin, Syndecan-1, biomarkers, Haematoxylin, H&E stains",

author = "Logan, {Jessica M.} and Carmela Martini and Alexandra Sorvina and Johnson, {Ian R.D.} and Brooks, {Robert D.} and Caruso, {Maria C.} and Chelsea Huzzell and Moore, {Courtney R.} and Litsa Karageorgos and Butler, {Lisa M.} and Prerna Tewari and Sarita Prabhakaran and Hickey, {Shane M.} and Sonja Klebe and Hemamali Samaratunga and Brett Delahunt and Kim Moretti and O{\textquoteright}Leary, {John J.} and Brooks, {Douglas A.} and Ung, {Ben S.Y.}",

year = "2024",

month = dec,

doi = "10.1038/s41597-024-03696-0",

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Logan, JM, Martini, C, Sorvina, A, Johnson, IRD, Brooks, RD, Caruso, MC, Huzzell, C, Moore, CR, Karageorgos, L, Butler, LM, Tewari, P, Prabhakaran, S, Hickey, SM, Klebe, S, Samaratunga, H, Delahunt, B, Moretti, K, O’Leary, JJ, Brooks, DA & Ung, BSY 2024, 'Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers', Scientific Data, vol. 11, no. 1, 852. https://doi.org/10.1038/s41597-024-03696-0

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AU - Logan, Jessica M.

AU - Martini, Carmela

AU - Sorvina, Alexandra

AU - Johnson, Ian R.D.

AU - Brooks, Robert D.

AU - Caruso, Maria C.

AU - Huzzell, Chelsea

AU - Moore, Courtney R.

AU - Karageorgos, Litsa

AU - Butler, Lisa M.

AU - Tewari, Prerna

AU - Prabhakaran, Sarita

AU - Hickey, Shane M.

AU - Klebe, Sonja

AU - Samaratunga, Hemamali

AU - Delahunt, Brett

AU - Moretti, Kim

AU - O’Leary, John J.

AU - Brooks, Douglas A.

AU - Ung, Ben S.Y.

PY - 2024/12

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KW - Histopathology

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KW - Sortilin

KW - Syndecan-1

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KW - Haematoxylin

KW - H&E stains

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JO - Scientific Data

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ER -

Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Abstract

Keywords

UN SDGs

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