Abstract
Introduction: Clinic studies have suggested a link between OSA and
chronic kidney disease (CKD), but the only population-based study was
in older adults (mean age 73 y) and did not show an independent
association. We determined the association of OSA, CKD and
co-morbidities in a community-based population of middle-aged and
older men.
Methods: A random sample of men without a previous diagnosis of
OSA (n = 837) from the Men Androgens Inflammation Lifestyle Environment
and Stress (MAILES) Study (a population cohort) undertook at
home 8-channel polysomnography (PSG). Extensive biomedical and
questionnaire based assessment of risk factors, and comorbidities
occurred. Renal function was classified using the Cockcroft-Gault equation
to calculate glomerular filtration rate (GFR, ml/min/1.73 m2). CKD
was defined as a GFR < 60 (stage 3).
Results: CKD occurred in 3.5% (n = 28) while 21.6% (n = 173)
showed a GFR 60–89 (stage 2), similar to National Health Survey
figures. Mean age of the cohort was 58 yr (standard deviation = 11).
CKD was not significantly associated with OSA (p = 0.59) and occurred
in 3.1% (n = 12) of men without OSA [apnoea hypopnea index (AHI)
<10] compared with 3.8% (n = 16) in men with OSA (AHI ≥ 10). OSA
was present in 57.1% (n = 16) of those with CKD compared to 52.0%
(n = 402) of those without CKD. No significant relationship was seen for
measures of nocturnal hypoxemia including oxygen desaturation index
(ODI) > 16/hr or total sleep with oxygen desaturation <90% (TST90)
<4% (75th percentile). When CKD stages were considered, GFR 60–89
was significantly more common in men with OSA [26.6% (n = 111)]
than those with no OSA [16.2% (62)]. In multinomial regression analysis
adjusted for age and hypertension, OSA was associated with GFR 60–89 [odds ratio (OR), 95% confidence interval (CI)]: 1.6 (1.1–2.3),
p = 0.02, but not GFR < 60: 1.1 (0.5–2.4). ODI > 16 and TST90 > 4%
showed no significant associations with GFR 60–89.
Conclusion: Impaired renal function (GFR 60–89) but not CKD, was
associated with OSA, an unselected, community-dwelling sample of
middle-aged and older men. The number of men with CKD is a study
limitation.
Original language | English |
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Article number | 062 |
Pages (from-to) | 19 |
Number of pages | 1 |
Journal | Sleep and Biological Rhythms |
Volume | 13 |
Issue number | S1 |
DOIs | |
Publication status | Published - Oct 2015 |
Event | Sleep Down Under 2015 Cycles - Melbourne, Australia Duration: 22 Oct 2015 → 24 Oct 2015 Conference number: 27th |