Relationship Between Obstructive Sleep Apnea (OSA) And Chronic Kidney Disease (CKD)

Robert Adams; Sarah Appleton; Andrew Vakulin; Carol Lang; Anne Taylor; Nick Antic; Peter Catcheside; Doug McEvoy; Gary Wittert

doi:10.1111/sbr.12132

Abstract

Introduction: Clinic studies have suggested a link between OSA and chronic kidney disease (CKD), but the only population-based study was in older adults (mean age 73 y) and did not show an independent association. We determined the association of OSA, CKD and co-morbidities in a community-based population of middle-aged and older men. Methods: A random sample of men without a previous diagnosis of OSA (n = 837) from the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (a population cohort) undertook at home 8-channel polysomnography (PSG). Extensive biomedical and questionnaire based assessment of risk factors, and comorbidities occurred. Renal function was classified using the Cockcroft-Gault equation to calculate glomerular filtration rate (GFR, ml/min/1.73 m2). CKD was defined as a GFR < 60 (stage 3). Results: CKD occurred in 3.5% (n = 28) while 21.6% (n = 173) showed a GFR 60–89 (stage 2), similar to National Health Survey figures. Mean age of the cohort was 58 yr (standard deviation = 11). CKD was not significantly associated with OSA (p = 0.59) and occurred in 3.1% (n = 12) of men without OSA [apnoea hypopnea index (AHI) <10] compared with 3.8% (n = 16) in men with OSA (AHI ≥ 10). OSA was present in 57.1% (n = 16) of those with CKD compared to 52.0% (n = 402) of those without CKD. No significant relationship was seen for measures of nocturnal hypoxemia including oxygen desaturation index (ODI) > 16/hr or total sleep with oxygen desaturation <90% (TST90) <4% (75th percentile). When CKD stages were considered, GFR 60–89 was significantly more common in men with OSA [26.6% (n = 111)] than those with no OSA [16.2% (62)]. In multinomial regression analysis adjusted for age and hypertension, OSA was associated with GFR 60–89 [odds ratio (OR), 95% confidence interval (CI)]: 1.6 (1.1–2.3), p = 0.02, but not GFR < 60: 1.1 (0.5–2.4). ODI > 16 and TST90 > 4% showed no significant associations with GFR 60–89. Conclusion: Impaired renal function (GFR 60–89) but not CKD, was associated with OSA, an unselected, community-dwelling sample of middle-aged and older men. The number of men with CKD is a study limitation.

Original language	English
Article number	062
Pages (from-to)	19
Number of pages	1
Journal	Sleep and Biological Rhythms
Volume	13
Issue number	S1
DOIs	https://doi.org/10.1111/sbr.12132
Publication status	Published - Oct 2015
Event	Sleep Down Under 2015 Cycles - Melbourne, Australia Duration: 22 Oct 2015 → 24 Oct 2015 Conference number: 27th

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@article{a3df78ebc59c4cb0868c7d9616955b87,

title = "Relationship Between Obstructive Sleep Apnea (OSA) And Chronic Kidney Disease (CKD)",

abstract = "Introduction: Clinic studies have suggested a link between OSA and chronic kidney disease (CKD), but the only population-based study was in older adults (mean age 73 y) and did not show an independent association. We determined the association of OSA, CKD and co-morbidities in a community-based population of middle-aged and older men. Methods: A random sample of men without a previous diagnosis of OSA (n = 837) from the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (a population cohort) undertook at home 8-channel polysomnography (PSG). Extensive biomedical and questionnaire based assessment of risk factors, and comorbidities occurred. Renal function was classified using the Cockcroft-Gault equation to calculate glomerular filtration rate (GFR, ml/min/1.73 m2). CKD was defined as a GFR < 60 (stage 3). Results: CKD occurred in 3.5% (n = 28) while 21.6% (n = 173) showed a GFR 60–89 (stage 2), similar to National Health Survey figures. Mean age of the cohort was 58 yr (standard deviation = 11). CKD was not significantly associated with OSA (p = 0.59) and occurred in 3.1% (n = 12) of men without OSA [apnoea hypopnea index (AHI) <10] compared with 3.8% (n = 16) in men with OSA (AHI ≥ 10). OSA was present in 57.1% (n = 16) of those with CKD compared to 52.0% (n = 402) of those without CKD. No significant relationship was seen for measures of nocturnal hypoxemia including oxygen desaturation index (ODI) > 16/hr or total sleep with oxygen desaturation <90% (TST90) <4% (75th percentile). When CKD stages were considered, GFR 60–89 was significantly more common in men with OSA [26.6% (n = 111)] than those with no OSA [16.2% (62)]. In multinomial regression analysis adjusted for age and hypertension, OSA was associated with GFR 60–89 [odds ratio (OR), 95% confidence interval (CI)]: 1.6 (1.1–2.3), p = 0.02, but not GFR < 60: 1.1 (0.5–2.4). ODI > 16 and TST90 > 4% showed no significant associations with GFR 60–89. Conclusion: Impaired renal function (GFR 60–89) but not CKD, was associated with OSA, an unselected, community-dwelling sample of middle-aged and older men. The number of men with CKD is a study limitation.",

author = "Robert Adams and Sarah Appleton and Andrew Vakulin and Carol Lang and Anne Taylor and Nick Antic and Peter Catcheside and Doug McEvoy and Gary Wittert",

year = "2015",

month = oct,

doi = "10.1111/sbr.12132",

language = "English",

volume = "13",

pages = "19",

journal = "Sleep and Biological Rhythms",

issn = "1446-9235",

number = "S1",

note = "Sleep Down Under 2015 Cycles ; Conference date: 22-10-2015 Through 24-10-2015",

}

Relationship Between Obstructive Sleep Apnea (OSA) And Chronic Kidney Disease (CKD). / Adams, Robert ; Appleton, Sarah ; Vakulin, Andrew; Lang, Carol; Taylor, Anne; Antic, Nick; Catcheside, Peter ; McEvoy, Doug; Wittert, Gary.

In: Sleep and Biological Rhythms, Vol. 13, No. S1, 062, 10.2015, p. 19.

Research output: Contribution to journal › Meeting Abstract › peer-review

TY - JOUR

T1 - Relationship Between Obstructive Sleep Apnea (OSA) And Chronic Kidney Disease (CKD)

AU - Adams, Robert

AU - Appleton, Sarah

AU - Vakulin, Andrew

AU - Lang, Carol

AU - Taylor, Anne

AU - Antic, Nick

AU - Catcheside, Peter

AU - McEvoy, Doug

AU - Wittert, Gary

N1 - Conference code: 27th

PY - 2015/10

Y1 - 2015/10

N2 - Introduction: Clinic studies have suggested a link between OSA and chronic kidney disease (CKD), but the only population-based study was in older adults (mean age 73 y) and did not show an independent association. We determined the association of OSA, CKD and co-morbidities in a community-based population of middle-aged and older men. Methods: A random sample of men without a previous diagnosis of OSA (n = 837) from the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (a population cohort) undertook at home 8-channel polysomnography (PSG). Extensive biomedical and questionnaire based assessment of risk factors, and comorbidities occurred. Renal function was classified using the Cockcroft-Gault equation to calculate glomerular filtration rate (GFR, ml/min/1.73 m2). CKD was defined as a GFR < 60 (stage 3). Results: CKD occurred in 3.5% (n = 28) while 21.6% (n = 173) showed a GFR 60–89 (stage 2), similar to National Health Survey figures. Mean age of the cohort was 58 yr (standard deviation = 11). CKD was not significantly associated with OSA (p = 0.59) and occurred in 3.1% (n = 12) of men without OSA [apnoea hypopnea index (AHI) <10] compared with 3.8% (n = 16) in men with OSA (AHI ≥ 10). OSA was present in 57.1% (n = 16) of those with CKD compared to 52.0% (n = 402) of those without CKD. No significant relationship was seen for measures of nocturnal hypoxemia including oxygen desaturation index (ODI) > 16/hr or total sleep with oxygen desaturation <90% (TST90) <4% (75th percentile). When CKD stages were considered, GFR 60–89 was significantly more common in men with OSA [26.6% (n = 111)] than those with no OSA [16.2% (62)]. In multinomial regression analysis adjusted for age and hypertension, OSA was associated with GFR 60–89 [odds ratio (OR), 95% confidence interval (CI)]: 1.6 (1.1–2.3), p = 0.02, but not GFR < 60: 1.1 (0.5–2.4). ODI > 16 and TST90 > 4% showed no significant associations with GFR 60–89. Conclusion: Impaired renal function (GFR 60–89) but not CKD, was associated with OSA, an unselected, community-dwelling sample of middle-aged and older men. The number of men with CKD is a study limitation.

AB - Introduction: Clinic studies have suggested a link between OSA and chronic kidney disease (CKD), but the only population-based study was in older adults (mean age 73 y) and did not show an independent association. We determined the association of OSA, CKD and co-morbidities in a community-based population of middle-aged and older men. Methods: A random sample of men without a previous diagnosis of OSA (n = 837) from the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (a population cohort) undertook at home 8-channel polysomnography (PSG). Extensive biomedical and questionnaire based assessment of risk factors, and comorbidities occurred. Renal function was classified using the Cockcroft-Gault equation to calculate glomerular filtration rate (GFR, ml/min/1.73 m2). CKD was defined as a GFR < 60 (stage 3). Results: CKD occurred in 3.5% (n = 28) while 21.6% (n = 173) showed a GFR 60–89 (stage 2), similar to National Health Survey figures. Mean age of the cohort was 58 yr (standard deviation = 11). CKD was not significantly associated with OSA (p = 0.59) and occurred in 3.1% (n = 12) of men without OSA [apnoea hypopnea index (AHI) <10] compared with 3.8% (n = 16) in men with OSA (AHI ≥ 10). OSA was present in 57.1% (n = 16) of those with CKD compared to 52.0% (n = 402) of those without CKD. No significant relationship was seen for measures of nocturnal hypoxemia including oxygen desaturation index (ODI) > 16/hr or total sleep with oxygen desaturation <90% (TST90) <4% (75th percentile). When CKD stages were considered, GFR 60–89 was significantly more common in men with OSA [26.6% (n = 111)] than those with no OSA [16.2% (62)]. In multinomial regression analysis adjusted for age and hypertension, OSA was associated with GFR 60–89 [odds ratio (OR), 95% confidence interval (CI)]: 1.6 (1.1–2.3), p = 0.02, but not GFR < 60: 1.1 (0.5–2.4). ODI > 16 and TST90 > 4% showed no significant associations with GFR 60–89. Conclusion: Impaired renal function (GFR 60–89) but not CKD, was associated with OSA, an unselected, community-dwelling sample of middle-aged and older men. The number of men with CKD is a study limitation.

U2 - 10.1111/sbr.12132

DO - 10.1111/sbr.12132

M3 - Meeting Abstract

VL - 13

SP - 19

JO - Sleep and Biological Rhythms

JF - Sleep and Biological Rhythms

SN - 1446-9235

IS - S1

M1 - 062

T2 - Sleep Down Under 2015 Cycles

Y2 - 22 October 2015 through 24 October 2015

ER -