Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi

William Johnston; Nora Mutalima; David Sun; Benjamin Emmanuel; Kishor Bhatia; Peter Aka; Xiao Lin Wu; Eric Borgstein; George Liomba; Steve Kamiza; Nyengo Mkandawire; Mkume Batumba; Lucy Carpenter; Harold Jaffe; Elizabeth Molyneux; James Goedert; Daniel Soppet; Robert Newton; Sam Mbulaiteye

doi:10.1038/srep03741

Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi

William Johnston, Nora Mutalima, David Sun, Benjamin Emmanuel, Kishor Bhatia, Peter Aka, Xiao Lin Wu, Eric Borgstein, George Liomba, Steve Kamiza, Nyengo Mkandawire, Mkume Batumba, Lucy Carpenter, Harold Jaffe, Elizabeth Molyneux, James Goedert, Daniel Soppet, Robert Newton, Sam Mbulaiteye

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Abstract

Endemic Burkitt lymphoma (eBL) has been linked to Plasmodium falciparum (Pf) malaria infection, but the contribution of infection with multiple Pf genotypes is uncertain. We studied 303 eBL (cases) and 274 non eBL-related cancers (controls) in Malawi using a sensitive and specific molecular-barcode array of 24 independently segregating Pf single nucleotide polymorphisms. Cases had a higher Pf malaria prevalence than controls (64.7% versus 45.3%; odds ratio [OR] 2.1, 95% confidence interval (CI): 1.5 to 3.1). Cases and controls were similar in terms of Pf density (4.9 versus 4.5 log copies, p = 0.28) and having ≥3 non-clonal calls (OR 2.7, 95% CI: 0.7-9.9, P = 0.14). However, cases were more likely to have a higher Pf genetic diversity score (153.9 versus 133.1, p = 0.036), which measures a combination of clonal and non-clonal calls, than controls. Further work is needed to evaluate the possible role of Pf genetic diversity in the pathogenesis of endemic BL.

Original language	English
Article number	3741
Number of pages	5
Journal	Scientific Reports
Volume	4
Issue number	3741
DOIs	https://doi.org/10.1038/srep03741
Publication status	Published - 17 Jan 2014

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Johnston, W., Mutalima, N., Sun, D., Emmanuel, B., Bhatia, K., Aka, P., Wu, X. L., Borgstein, E., Liomba, G., Kamiza, S., Mkandawire, N., Batumba, M., Carpenter, L., Jaffe, H., Molyneux, E., Goedert, J., Soppet, D., Newton, R., & Mbulaiteye, S. (2014). Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi. Scientific Reports, 4(3741), Article 3741. https://doi.org/10.1038/srep03741

@article{3fc430af2a8f44649cb5b23a4a979ee3,

title = "Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi",

abstract = "Endemic Burkitt lymphoma (eBL) has been linked to Plasmodium falciparum (Pf) malaria infection, but the contribution of infection with multiple Pf genotypes is uncertain. We studied 303 eBL (cases) and 274 non eBL-related cancers (controls) in Malawi using a sensitive and specific molecular-barcode array of 24 independently segregating Pf single nucleotide polymorphisms. Cases had a higher Pf malaria prevalence than controls (64.7% versus 45.3%; odds ratio [OR] 2.1, 95% confidence interval (CI): 1.5 to 3.1). Cases and controls were similar in terms of Pf density (4.9 versus 4.5 log copies, p = 0.28) and having ≥3 non-clonal calls (OR 2.7, 95% CI: 0.7-9.9, P = 0.14). However, cases were more likely to have a higher Pf genetic diversity score (153.9 versus 133.1, p = 0.036), which measures a combination of clonal and non-clonal calls, than controls. Further work is needed to evaluate the possible role of Pf genetic diversity in the pathogenesis of endemic BL.",

author = "William Johnston and Nora Mutalima and David Sun and Benjamin Emmanuel and Kishor Bhatia and Peter Aka and Wu, {Xiao Lin} and Eric Borgstein and George Liomba and Steve Kamiza and Nyengo Mkandawire and Mkume Batumba and Lucy Carpenter and Harold Jaffe and Elizabeth Molyneux and James Goedert and Daniel Soppet and Robert Newton and Sam Mbulaiteye",

year = "2014",

month = jan,

day = "17",

doi = "10.1038/srep03741",

language = "English",

volume = "4",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "3741",

}

Johnston, W, Mutalima, N, Sun, D, Emmanuel, B, Bhatia, K, Aka, P, Wu, XL, Borgstein, E, Liomba, G, Kamiza, S, Mkandawire, N, Batumba, M, Carpenter, L, Jaffe, H, Molyneux, E, Goedert, J, Soppet, D, Newton, R & Mbulaiteye, S 2014, 'Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi', Scientific Reports, vol. 4, no. 3741, 3741. https://doi.org/10.1038/srep03741

Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi

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