Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus

Renata Libianto; John Moran; Christopher O'Callaghan; Sara Baqar; Angela X. Chen; Scott T. Baker; Michelle Clarke; Richard J. MacIsaac; George Jerums; Elif I. Ekinci

doi:10.1111/1440-1681.12852

Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus

Renata Libianto, John Moran, Christopher O'Callaghan, Sara Baqar, Angela X. Chen, Scott T. Baker, Michelle Clarke, Richard J. MacIsaac, George Jerums, Elif I. Ekinci

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R² = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	45
Issue number	1
DOIs	https://doi.org/10.1111/1440-1681.12852
Publication status	Published - Jan 2018
Externally published	Yes

Bibliographical note

Funding Information:
Dr Ekinci was supported by an NHMRC Early Career Fellowship (Part Time), Charles and Sylvia Viertel Clinical Investigatorship, Sir Edward Dunlop Medical Research Foundation grant and Diabetes Australia Research Program Research Grant.

Publisher Copyright:
© 2017 John Wiley & Sons Australia, Ltd

Keywords

ambulatory blood pressure
diabetes
potassium
sodium
urinary electrolytes

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Libianto, R., Moran, J., O'Callaghan, C., Baqar, S., Chen, A. X., Baker, S. T., Clarke, M., MacIsaac, R. J., Jerums, G., & Ekinci, E. I. (2018). Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus. Clinical and Experimental Pharmacology and Physiology, 45(1), 94-97. https://doi.org/10.1111/1440-1681.12852

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abstract = "Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R2 = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.",

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author = "Renata Libianto and John Moran and Christopher O'Callaghan and Sara Baqar and Chen, {Angela X.} and Baker, {Scott T.} and Michelle Clarke and MacIsaac, {Richard J.} and George Jerums and Ekinci, {Elif I.}",

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AU - O'Callaghan, Christopher

AU - Baqar, Sara

AU - Chen, Angela X.

AU - Baker, Scott T.

AU - Clarke, Michelle

AU - MacIsaac, Richard J.

AU - Jerums, George

AU - Ekinci, Elif I.

N1 - Funding Information: Dr Ekinci was supported by an NHMRC Early Career Fellowship (Part Time), Charles and Sylvia Viertel Clinical Investigatorship, Sir Edward Dunlop Medical Research Foundation grant and Diabetes Australia Research Program Research Grant. Publisher Copyright: © 2017 John Wiley & Sons Australia, Ltd

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Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus

Abstract

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Keywords

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