Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus

Renata Libianto, John Moran, Christopher O'Callaghan, Sara Baqar, Angela X. Chen, Scott T. Baker, Michelle Clarke, Richard J. MacIsaac, George Jerums, Elif I. Ekinci

Research output: Contribution to journalLetterpeer-review

2 Citations (Scopus)

Abstract

Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R2 = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2018
Externally publishedYes

Bibliographical note

Funding Information:
Dr Ekinci was supported by an NHMRC Early Career Fellowship (Part Time), Charles and Sylvia Viertel Clinical Investigatorship, Sir Edward Dunlop Medical Research Foundation grant and Diabetes Australia Research Program Research Grant.

Publisher Copyright:
© 2017 John Wiley & Sons Australia, Ltd

Keywords

  • ambulatory blood pressure
  • diabetes
  • potassium
  • sodium
  • urinary electrolytes

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