Relationships between changes in symptom ratings, neuropsychological test performance and quality of life in schizophrenic patients treated with clozapine

Cherrie A. Galletly, C. Richard Clark, Alexander C. McFarlane, Darren L. Weber

    Research output: Contribution to journalArticlepeer-review

    103 Citations (Scopus)

    Abstract

    This study examined the correlations between reduction in symptoms, changes in neuropsychological test performance and improved quality of life in 19 schizophrenic outpatients treated with clozapine. Reduction in both negative symptoms and general psychopathology was associated with a better quality of life. Some improvement in neuropsychological test performance was found, with a variable pattern of association with change in psychopathology. Improved verbal fluency was associated with reduction in negative symptoms, while improved verbal concept formation was associated with reduction in positive symptoms.

    Original languageEnglish
    Pages (from-to)161-166
    Number of pages6
    JournalPsychiatry Research
    Volume72
    Issue number3
    DOIs
    Publication statusPublished - 10 Oct 1997

    Keywords

    • Cognition
    • Negative symptoms
    • Positive symptoms

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