Relationships between plasma theophylline clearance, liver volume and body weight in children and adults

J. J. Grygiel, H. Ward, M. Ogborne, A. Goldin, D. J. Birkett

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults. A linear relationship (r=+0.99) was demonstrated between ideal body weight and liver volume estimated by an ultrasonic scanning technique. Age-related changes in liver volume-to-body weight ratio could account for only 30% of differences in plasma theophylline clearance (l/h/kg) between children and adults. It is summized that increased hepatic mixed function oxidase activity is the major contributor to the higher plasma theophylline clearance in children.

    Original languageEnglish
    Pages (from-to)529-532
    Number of pages4
    JournalEuropean Journal of Clinical Pharmacology
    Volume24
    Issue number4
    DOIs
    Publication statusPublished - Jul 1983

    Keywords

    • asthma
    • body weight
    • liver volume
    • theophylline clearance
    • ultrasound

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