Abstract
The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults. A linear relationship (r=+0.99) was demonstrated between ideal body weight and liver volume estimated by an ultrasonic scanning technique. Age-related changes in liver volume-to-body weight ratio could account for only 30% of differences in plasma theophylline clearance (l/h/kg) between children and adults. It is summized that increased hepatic mixed function oxidase activity is the major contributor to the higher plasma theophylline clearance in children.
| Original language | English |
|---|---|
| Pages (from-to) | 529-532 |
| Number of pages | 4 |
| Journal | European Journal of Clinical Pharmacology |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1983 |
Keywords
- asthma
- body weight
- liver volume
- theophylline clearance
- ultrasound