Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit

Paul Pilowsky; Malcolm West; John Chalmers

doi:10.1016/0304-3940(85)90380-5

Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit

Paul Pilowsky, Malcolm West, John Chalmers

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The role of the sympathetic nervous system in the cardiovascular responses to lesions of the caudal ventrolateral medulla of the rabbit was investigated by measurement of renal sympathetic nerve activity. In addition, the effect of chemical stimulation and inhibition on renal sympathetic nerve activity was assessed. The results show that lesions or chemical inhibition of the caudal ventrolateral medulla result in an increase in sympathetic nerve activity and blood pressure, whilst excitation results in a decrease in blood pressure and nerve activity. These findings contrast with chemical stimulation or inhibition of the rostral ventrolateral medulla in the region of the C1 cells where stimulation results in a rise in blood pressure and renal nerve activity, and inhibition, a fall in blood pressure and nerve activity.

Original language	English
Pages (from-to)	51-55
Number of pages	5
Journal	Neuroscience letters
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(85)90380-5
Publication status	Published - 16 Sep 1985
Externally published	Yes

Keywords

A1 cell
blood pressure
C1 cell
heart rate
rabbit
renal nerve
sympathetic nerve activity
vaso-pressin
ventrolateral medulla

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abstract = "The role of the sympathetic nervous system in the cardiovascular responses to lesions of the caudal ventrolateral medulla of the rabbit was investigated by measurement of renal sympathetic nerve activity. In addition, the effect of chemical stimulation and inhibition on renal sympathetic nerve activity was assessed. The results show that lesions or chemical inhibition of the caudal ventrolateral medulla result in an increase in sympathetic nerve activity and blood pressure, whilst excitation results in a decrease in blood pressure and nerve activity. These findings contrast with chemical stimulation or inhibition of the rostral ventrolateral medulla in the region of the C1 cells where stimulation results in a rise in blood pressure and renal nerve activity, and inhibition, a fall in blood pressure and nerve activity.",

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AU - West, Malcolm

AU - Chalmers, John

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N2 - The role of the sympathetic nervous system in the cardiovascular responses to lesions of the caudal ventrolateral medulla of the rabbit was investigated by measurement of renal sympathetic nerve activity. In addition, the effect of chemical stimulation and inhibition on renal sympathetic nerve activity was assessed. The results show that lesions or chemical inhibition of the caudal ventrolateral medulla result in an increase in sympathetic nerve activity and blood pressure, whilst excitation results in a decrease in blood pressure and nerve activity. These findings contrast with chemical stimulation or inhibition of the rostral ventrolateral medulla in the region of the C1 cells where stimulation results in a rise in blood pressure and renal nerve activity, and inhibition, a fall in blood pressure and nerve activity.

AB - The role of the sympathetic nervous system in the cardiovascular responses to lesions of the caudal ventrolateral medulla of the rabbit was investigated by measurement of renal sympathetic nerve activity. In addition, the effect of chemical stimulation and inhibition on renal sympathetic nerve activity was assessed. The results show that lesions or chemical inhibition of the caudal ventrolateral medulla result in an increase in sympathetic nerve activity and blood pressure, whilst excitation results in a decrease in blood pressure and nerve activity. These findings contrast with chemical stimulation or inhibition of the rostral ventrolateral medulla in the region of the C1 cells where stimulation results in a rise in blood pressure and renal nerve activity, and inhibition, a fall in blood pressure and nerve activity.

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KW - blood pressure

KW - C1 cell

KW - heart rate

KW - rabbit

KW - renal nerve

KW - sympathetic nerve activity

KW - vaso-pressin

KW - ventrolateral medulla

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Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit

Abstract

Keywords

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