RENAL TRANSPLANTATION AND A POSITIVE SEROLOGICAL CROSS-MATCH

P. J. Morris, D. O. Oliver, K. Williams, A. Ting, M. Bishop, M. S. Dunnill

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A renal transplant involving a recipient with a positive serological cross-match against donor lymphocytes generally results in hyperacute rejection of the graft. 13 cadaveric renal transplants were performed in recipients with a known positive serological cross-match against donor B lymphocytes. 12 of these serological cross-matches were positive against donor blood, node, or spleen lymphocytes, but the reactivity was directed against donor B lymphocytes only. 3 transplants failed, 2 because of rejection and 1 because of renal-artery thrombosis. 10 transplants are functioning, 6 to 42 weeks after the operation. Of these 10 successful grafts, 3 had no acute rejection episodes, while 7 had an early acute rejection episode which responded to treatment. Histologically, the grafts showed a cellular rejection, similar to that in enhanced renal allografts in the rat. It is possible to transplant a kidney in a high-risk patient with a positive B lymphocyte cross-match with a low risk of failure. In addition active enhancement of the graft might sometimes occur.

Original languageEnglish
Pages (from-to)1288-1291
Number of pages4
JournalThe Lancet
Volume309
Issue number8025
DOIs
Publication statusPublished - 18 Jun 1977
Externally publishedYes

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