Renewal Theory as a Universal Quantitative Framework to Characterize Phase Singularity Regeneration in Mammalian Cardiac Fibrillation

Dhani Dharmaprani, Madeline Schopp, Pawel Kuklik, Darius Chapman, Anandaroop Lahiri, Lukah Dykes, Feng Xiong, Martin Aguilar, Benjamin Strauss, Lewis Mitchell, Kenneth Pope, Christian Meyer, Stephan Willems, Fadi G Akar, Stanley Nattel, Andrew McGavigan, Anand Ganesan

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28 Citations (Scopus)


Despite a century of research, no clear quantitative framework exists to model the fundamental processes responsible for the continuous formation and destruction of phase singularities (PS) in cardiac fibrillation. We hypothesized PS formation/destruction in fibrillation could be modeled as self-regenerating Poisson renewal processes, producing exponential distributions of interevent times governed by constant rate parameters defined by the prevailing properties of each system.
PS formation/destruction were studied in 5 systems: (1) human persistent atrial fibrillation (n=20), (2) tachypaced sheep atrial fibrillation (n=5), (3) rat atrial fibrillation (n=4), (5) rat ventricular fibrillation (n=11), and (5) computer-simulated fibrillation. PS time-to-event data were fitted by exponential probability distribution functions computed using maximum entropy theory, and rates of PS formation and destruction (λf/λd) determined. A systematic review was conducted to cross-validate with source data from literature.
In all systems, PS lifetime and interformation times were consistent with underlying Poisson renewal processes (human: λf, 4.2%/ms±1.1 [95% CI, 4.0–5.0], λd, 4.6%/ms±1.5 [95% CI, 4.3–4.9]; sheep: λf, 4.4%/ms [95% CI, 4.1–4.7], λd, 4.6%/ms±1.4 [95% CI, 4.3–4.8]; rat atrial fibrillation: λf, 33%/ms±8.8 [95% CI, 11–55], λd, 38%/ms [95% CI, 22–55]; rat ventricular fibrillation: λf, 38%/ms±24 [95% CI, 22–55], λf, 46%/ms±21 [95% CI, 31–60]; simulated fibrillation λd, 6.6–8.97%/ms [95% CI, 4.1–6.7]; R2≥0.90 in all cases). All PS distributions identified through systematic review were also consistent with an underlying Poisson renewal process.
Poisson renewal theory provides an evolutionarily preserved universal framework to quantify formation and destruction of rotational events in cardiac fibrillation.
Original languageEnglish
Article numbere007569
Pages (from-to)e007569
Number of pages1
JournalCirculation: Arrhythmia and Electrophysiology
Issue number12
Publication statusPublished - Dec 2019


  • atrial fibrillation
  • phase singularities
  • renewal theory
  • stochastic processes
  • ventricular fibrillation


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