Reply to: Caution in inferring viral strategies from abundance correlations in marine metagenomes

F. H. Coutinho, C. B. Silveira, G. B. Gregoracci, C. C. Thompson, R. A. Edwards, C. P.D. Brussaard, B. E. Dutilh, F. L. Thompson

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Our publication by Coutinho et al.1 assembled viral genomes from marine viromes and linked these viral genomes to their potential hosts. We then investigated the relationship between the abundances of microbes (hosts) and virus-host-ratios (VHR) across samples (see Fig. 6 in ref. 1). We observed a decrease in VHR with increasing host abundance that is consistent with independent findings2,3. That result was interpreted in the discussion of our original publication as a relative decrease in lytic viral production. The decrease in VHR with increasing host abundance is consistent with the Piggyback-the-Winner (PtW) model, which proposes that lysogeny is the mechanism behind the decrease in VHR4. Al-Rasheed et al.5 criticized our interpretation arguing that the negative relationship reported for VHR and host abundance was not indicative of higher frequency of lysogeny.
Original languageEnglish
Article number502
Number of pages2
JournalNature Communications
Volume10
DOIs
Publication statusPublished - 30 Jan 2019
Externally publishedYes

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Keywords

  • marine metagenomes
  • inferring
  • viral
  • strategies

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    Coutinho, F. H., Silveira, C. B., Gregoracci, G. B., Thompson, C. C., Edwards, R. A., Brussaard, C. P. D., Dutilh, B. E., & Thompson, F. L. (2019). Reply to: Caution in inferring viral strategies from abundance correlations in marine metagenomes. Nature Communications, 10, [502]. https://doi.org/10.1038/s41467-018-08286-4