TY - JOUR
T1 - Reply to Satoshi Funada, Takashi Yoshioka, and Yan Luo's Letter to the Editor re
T2 - Ashley M. Hopkins, Ganessan Kichenadasse, Christos S. Karapetis, et al. Concomitant Antibiotic Use and Survival in Urothelial Carcinoma Treated with Atezolizumab. Eur Urol 2020;78:540–3
AU - Hopkins, Ashley M.
AU - Kichenadasse, Ganessan
AU - Sorich, Michael J.
PY - 2020/12
Y1 - 2020/12
N2 - We thank Funada et al for the comments on our Brief Correspondence in European Urology [1]. We agree that established guidelines for subgroup analyses are critical for promoting valid assessment of treatment effect heterogeneity and note that the comments (ie, the importance of clearly stating the post hoc nature of analysis, having a clear basis for undertaking the subgroup analysis, using a statistical test of treatment-by-covariate interaction, and cautious interpretation of findings) simply restate the existing appropriate methods, interpretation, and reporting in our manuscript [1]
AB - We thank Funada et al for the comments on our Brief Correspondence in European Urology [1]. We agree that established guidelines for subgroup analyses are critical for promoting valid assessment of treatment effect heterogeneity and note that the comments (ie, the importance of clearly stating the post hoc nature of analysis, having a clear basis for undertaking the subgroup analysis, using a statistical test of treatment-by-covariate interaction, and cautious interpretation of findings) simply restate the existing appropriate methods, interpretation, and reporting in our manuscript [1]
KW - Urothelial Carcinoma
KW - heterogeneity
KW - antibiotic use
UR - http://www.scopus.com/inward/record.url?scp=85091944630&partnerID=8YFLogxK
U2 - 10.1016/j.eururo.2020.09.021
DO - 10.1016/j.eururo.2020.09.021
M3 - Letter
C2 - 32958298
AN - SCOPUS:85091944630
SN - 0302-2838
VL - 78
SP - e227
JO - European Urology
JF - European Urology
IS - 6
ER -