Response to Letter to the Editor

Per Cajander, Taher Omari, Harry Scheinin, Mika Scheinin, Johanna Savilampi

Research output: Contribution to journalLetterpeer-review


It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct α2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.

Original languageEnglish
Article numbere14616
Number of pages2
JournalNeurogastroenterology and Motility
Issue number8
Early online date29 May 2023
Publication statusPublished - Aug 2023


  • dexmedetomidine
  • esophageal motility
  • pulmonary aspiration
  • sedatives
  • swallowing function


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