Response to Letter to the Editor

Per Cajander; Taher Omari; Harry Scheinin; Mika Scheinin; Johanna Savilampi

doi:10.1111/nmo.14616

Response to Letter to the Editor

Per Cajander, Taher Omari, Harry Scheinin, Mika Scheinin, Johanna Savilampi

College of Medicine and Public Health

Research output: Contribution to journal › Letter › peer-review

Abstract

It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct α2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.

Original language	English
Article number	e14616
Number of pages	2
Journal	Neurogastroenterology and Motility
Volume	35
Issue number	8
Early online date	29 May 2023
DOIs	https://doi.org/10.1111/nmo.14616
Publication status	Published - Aug 2023

Keywords

dexmedetomidine
esophageal motility
pulmonary aspiration
sedatives
swallowing function

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Response to Letter to the Editor

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Keywords

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