Resting-state Networks in Tinnitus: A Scoping Review

Tori Elyssa Kok, Deepti Domingo, Joshua Hassan, Alysha Vuong, Brenton Hordacre, Chris Clark, Panagiotis Katrakazas, Giriraj Singh Shekhawat

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic subjective tinnitus is the constant perception of a sound that has no physical source. Brain imaging studies show alterations in tinnitus patients’ resting-state networks (RSNs). This scoping review aims to provide an overview of resting-state fMRI studies in tinnitus, and to evaluate the evidence for changes in different RSNs. A total of 29 studies were included, 26 of which found alterations in networks such as the auditory network, default mode network, attention networks, and visual network; however, there is a lack of reproducibility in the field which can be attributed to the use of different regions of interest and analytical methods per study, and tinnitus heterogeneity. Future studies should focus on replication by using the same regions of interest in their analysis of resting-state data, and by controlling adequately for potential confounds. These efforts could potentially lead to the identification of a biomarker for tinnitus in the future.

Original languageEnglish
Number of pages20
JournalClinical Neuroradiology
Early online date12 May 2022
DOIs
Publication statusE-pub ahead of print - 12 May 2022

Keywords

  • Auditory network
  • Brain imaging
  • Functional magnetic resonance imaging
  • Neural networks
  • Review
  • Subjective tinnitus

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