Retinal biomarkers provide “insight” into cortical pharmacology and disease

Christine T.O. Nguyen; Flora Hui; Jason Charng; Shajan Velaedan; Anna K. van Koeverden; Jeremiah K.H. Lim; Zheng He; Vickie H.Y. Wong; Algis J. Vingrys; Bang V. Bui; Magnus Ivarsson

doi:10.1016/j.pharmthera.2017.02.009

Retinal biomarkers provide “insight” into cortical pharmacology and disease

Christine T.O. Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K. van Koeverden, Jeremiah K.H. Lim, Zheng He, Vickie H.Y. Wong, Algis J. Vingrys, Bang V. Bui, Magnus Ivarsson

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of the brain. More specifically, the presence of neuronal, vascular and blood-neural barrier parallels in the eye and brain coupled with fast and inexpensive methods to quantify retinal changes make ocular biomarkers an attractive option. This includes its utility as a biomarker for a number of cerebrovascular diseases as well as a drug pharmacology and safety biomarker for the CNS. It is a rapidly emerging field, with some areas well established, such as stroke risk and multiple sclerosis, whereas others are still in development (Alzheimer's, Parkinson's, psychological disease and cortical diabetic dysfunction). The current applications and future potential of retinal biomarkers, including potential ways to improve their sensitivity and specificity are discussed. This review summarises the existing literature and provides a perspective on the strength of current retinal biomarkers and their future potential.

Original language	English
Pages (from-to)	151-177
Number of pages	27
Journal	Pharmacology and Therapeutics
Volume	175
Early online date	5 Feb 2017
DOIs	https://doi.org/10.1016/j.pharmthera.2017.02.009
Publication status	Published - Jul 2017
Externally published	Yes

Keywords

Biomarker
Brain
Disease
Eye
Pharmacology
Retina

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Retinal biomarkers provide “insight” into cortical pharmacology and disease",

abstract = "The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of the brain. More specifically, the presence of neuronal, vascular and blood-neural barrier parallels in the eye and brain coupled with fast and inexpensive methods to quantify retinal changes make ocular biomarkers an attractive option. This includes its utility as a biomarker for a number of cerebrovascular diseases as well as a drug pharmacology and safety biomarker for the CNS. It is a rapidly emerging field, with some areas well established, such as stroke risk and multiple sclerosis, whereas others are still in development (Alzheimer's, Parkinson's, psychological disease and cortical diabetic dysfunction). The current applications and future potential of retinal biomarkers, including potential ways to improve their sensitivity and specificity are discussed. This review summarises the existing literature and provides a perspective on the strength of current retinal biomarkers and their future potential.",

keywords = "Biomarker, Brain, Disease, Eye, Pharmacology, Retina",

author = "Nguyen, {Christine T.O.} and Flora Hui and Jason Charng and Shajan Velaedan and {van Koeverden}, {Anna K.} and Lim, {Jeremiah K.H.} and Zheng He and Wong, {Vickie H.Y.} and Vingrys, {Algis J.} and Bui, {Bang V.} and Magnus Ivarsson",

year = "2017",

month = jul,

doi = "10.1016/j.pharmthera.2017.02.009",

language = "English",

volume = "175",

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journal = "Pharmacology and Therapeutics",

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AU - Nguyen, Christine T.O.

AU - Hui, Flora

AU - Charng, Jason

AU - Velaedan, Shajan

AU - van Koeverden, Anna K.

AU - Lim, Jeremiah K.H.

AU - He, Zheng

AU - Wong, Vickie H.Y.

AU - Vingrys, Algis J.

AU - Bui, Bang V.

AU - Ivarsson, Magnus

PY - 2017/7

Y1 - 2017/7

N2 - The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of the brain. More specifically, the presence of neuronal, vascular and blood-neural barrier parallels in the eye and brain coupled with fast and inexpensive methods to quantify retinal changes make ocular biomarkers an attractive option. This includes its utility as a biomarker for a number of cerebrovascular diseases as well as a drug pharmacology and safety biomarker for the CNS. It is a rapidly emerging field, with some areas well established, such as stroke risk and multiple sclerosis, whereas others are still in development (Alzheimer's, Parkinson's, psychological disease and cortical diabetic dysfunction). The current applications and future potential of retinal biomarkers, including potential ways to improve their sensitivity and specificity are discussed. This review summarises the existing literature and provides a perspective on the strength of current retinal biomarkers and their future potential.

AB - The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of the brain. More specifically, the presence of neuronal, vascular and blood-neural barrier parallels in the eye and brain coupled with fast and inexpensive methods to quantify retinal changes make ocular biomarkers an attractive option. This includes its utility as a biomarker for a number of cerebrovascular diseases as well as a drug pharmacology and safety biomarker for the CNS. It is a rapidly emerging field, with some areas well established, such as stroke risk and multiple sclerosis, whereas others are still in development (Alzheimer's, Parkinson's, psychological disease and cortical diabetic dysfunction). The current applications and future potential of retinal biomarkers, including potential ways to improve their sensitivity and specificity are discussed. This review summarises the existing literature and provides a perspective on the strength of current retinal biomarkers and their future potential.

KW - Biomarker

KW - Brain

KW - Disease

KW - Eye

KW - Pharmacology

KW - Retina

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U2 - 10.1016/j.pharmthera.2017.02.009

DO - 10.1016/j.pharmthera.2017.02.009

M3 - Review article

C2 - 28174096

AN - SCOPUS:85014127635

SN - 0163-7258

VL - 175

SP - 151

EP - 177

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

ER -

Retinal biomarkers provide “insight” into cortical pharmacology and disease

Abstract

Keywords

UN SDGs

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