Retinal-specific dopamine knock-out mice are myopic

Michael A. Bergen, Hanna Park, Ranjay Chakraborty, Erica G. Landis, Curran Sidhu, P. Michael Iuvone, Machelle t. Pardue

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Dopamine has been implicated as a stop signal for refractive eye growth based on pharmacological studies in chickens, mammals, and primates. More recently, dopamine receptor knock-out mice have been used to elucidate dopaminergic mechanisms of refractive development (Huang et al. IOVS 2014). In this study, a Cre-mediated, retinal-specific tyrosine hydroxylase knockout (KO) mouse was studied to determine the effect of eliminating retinal dopamine on refractive development and susceptibility to form deprivation (FD) myopia.
Original languageEnglish
Number of pages2
Publication statusPublished - 2015
Externally publishedYes
EventThe Association for Research in Vision and Ophthalmology annual meeting 2012 - Fort Lauderdale Convention Center, Fort Lauderdale, United States
Duration: 6 May 201210 May 2012
Conference number: 14

Conference

ConferenceThe Association for Research in Vision and Ophthalmology annual meeting 2012
Abbreviated titleARVO 2012
CountryUnited States
CityFort Lauderdale
Period6/05/1210/05/12

Keywords

  • Dopamine
  • refractive eye growth
  • mice
  • myopia

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