Retinal-specific dopamine knock-out mice are myopic

Michael A. Bergen; Hanna Park; Ranjay Chakraborty; Erica G. Landis; Curran Sidhu; P. Michael Iuvone; Machelle t. Pardue

Retinal-specific dopamine knock-out mice are myopic

Michael A. Bergen, Hanna Park, Ranjay Chakraborty, Erica G. Landis, Curran Sidhu, P. Michael Iuvone, Machelle t. Pardue

Research output: Contribution to conference › Abstract › peer-review

Abstract

Dopamine has been implicated as a stop signal for refractive eye growth based on pharmacological studies in chickens, mammals, and primates. More recently, dopamine receptor knock-out mice have been used to elucidate dopaminergic mechanisms of refractive development (Huang et al. IOVS 2014). In this study, a Cre-mediated, retinal-specific tyrosine hydroxylase knockout (KO) mouse was studied to determine the effect of eliminating retinal dopamine on refractive development and susceptibility to form deprivation (FD) myopia.

Original language	English
Number of pages	2
Publication status	Published - 2015
Externally published	Yes
Event	The Association for Research in Vision and Ophthalmology annual meeting 2012 - Fort Lauderdale Convention Center, Fort Lauderdale, United States Duration: 6 May 2012 → 10 May 2012 Conference number: 14

Conference

Conference	The Association for Research in Vision and Ophthalmology annual meeting 2012
Abbreviated title	ARVO 2012
Country/Territory	United States
City	Fort Lauderdale
Period	6/05/12 → 10/05/12

Keywords

Dopamine
refractive eye growth
mice
myopia

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https://iovs.arvojournals.org/article.aspx?articleid=2331905&resultClick=1Licence: In Copyright

Cite this

@conference{b13db860b5634e6b89d5360dfdee8ca6,

title = "Retinal-specific dopamine knock-out mice are myopic",

abstract = " Dopamine has been implicated as a stop signal for refractive eye growth based on pharmacological studies in chickens, mammals, and primates. More recently, dopamine receptor knock-out mice have been used to elucidate dopaminergic mechanisms of refractive development (Huang et al. IOVS 2014). In this study, a Cre-mediated, retinal-specific tyrosine hydroxylase knockout (KO) mouse was studied to determine the effect of eliminating retinal dopamine on refractive development and susceptibility to form deprivation (FD) myopia.",

keywords = "Dopamine, refractive eye growth, mice, myopia",

author = "Bergen, {Michael A.} and Hanna Park and Ranjay Chakraborty and Landis, {Erica G.} and Curran Sidhu and Iuvone, {P. Michael} and Pardue, {Machelle t.}",

year = "2015",

language = "English",

note = "The Association for Research in Vision and Ophthalmology annual meeting 2012, ARVO 2012 ; Conference date: 06-05-2012 Through 10-05-2012",

}

TY - CONF

T1 - Retinal-specific dopamine knock-out mice are myopic

AU - Bergen, Michael A.

AU - Park, Hanna

AU - Chakraborty, Ranjay

AU - Landis, Erica G.

AU - Sidhu, Curran

AU - Iuvone, P. Michael

AU - Pardue, Machelle t.

N1 - Conference code: 14

PY - 2015

Y1 - 2015

N2 - Dopamine has been implicated as a stop signal for refractive eye growth based on pharmacological studies in chickens, mammals, and primates. More recently, dopamine receptor knock-out mice have been used to elucidate dopaminergic mechanisms of refractive development (Huang et al. IOVS 2014). In this study, a Cre-mediated, retinal-specific tyrosine hydroxylase knockout (KO) mouse was studied to determine the effect of eliminating retinal dopamine on refractive development and susceptibility to form deprivation (FD) myopia.

AB - Dopamine has been implicated as a stop signal for refractive eye growth based on pharmacological studies in chickens, mammals, and primates. More recently, dopamine receptor knock-out mice have been used to elucidate dopaminergic mechanisms of refractive development (Huang et al. IOVS 2014). In this study, a Cre-mediated, retinal-specific tyrosine hydroxylase knockout (KO) mouse was studied to determine the effect of eliminating retinal dopamine on refractive development and susceptibility to form deprivation (FD) myopia.

KW - Dopamine

KW - refractive eye growth

KW - mice

KW - myopia

M3 - Abstract

T2 - The Association for Research in Vision and Ophthalmology annual meeting 2012

Y2 - 6 May 2012 through 10 May 2012

ER -

Retinal-specific dopamine knock-out mice are myopic

Abstract

Conference

Keywords

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