Retinal Vein Occlusion and Vascular Mortality: Pooled Data Analysis of 2 Population-Based Cohorts

Sudha Cugati, Jie Jin Wang, Michael D. Knudtson, Elena Rochtchina, Ronald Klein, Barbara E.K. Klein, Tien Yin Wong, Paul Mitchell

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)


Purpose: To assess the association of retinal vein occlusion (RVO) with cardiovascular and cerebrovascular mortality. Design: Pooled data from 2 population-based cohort studies. Participants: At baseline, the Beaver Dam Eye Study (BDES) examined 4926 persons aged 43 to 86 years (from 1988-1990) and the Blue Mountains Eye Study (BMES) examined 3654 persons aged 49 to 97 years (from 1992 to 1994). Methods: Retinal vein occlusion was assessed from retinal photographs. Vascular deaths were determined using either death certificates (BDES) or the Australian National Death Index (BMES). Cox regression analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Main Outcome Measure: Vascular (cardiovascular and cerebrovascular) mortality was determined. Results: Of 8384 baseline participants, 96 (1.14%) had RVO at baseline (BDES, n = 38; BMES, n = 58). Over 12 years, 1312 (15.7%) died of cardiovascular-related conditions and 341 (4.1%) died of cerebrovascular-related conditions. Age-standardized vascular mortality rates were 26.0% and 5.3%, respectively, in persons with RVO and 17.1% and 4.5%, respectively, in those without RVO. After adjusting for age, gender, body mass index, hypertension, diabetes, smoking, glaucoma, and study site, RVO was not associated with cardiovascular-related mortality (HR, 1.2; 95% CI, 0.8-1.8) or cerebrovascular-related mortality (HR, 0.9; 95% CI, 0.4-2.1) among participants of all ages. However, in persons aged less than 70 years, baseline RVO was associated with higher cardiovascular mortality (combined BDES and BMES: HR, 2.5; 95% CI, 1.2-5.2; BDES: HR, 2.5; 95% CI, 0.9-6.9; BMES: HR, 2.1; 95% CI, 0.7-6.8). Conclusions: Retinal vein occlusion in persons aged 43 to 69 years may signal a doubling of the risk of cardiovascular mortality.

Original languageEnglish
Pages (from-to)520-524
Number of pages5
Issue number3
Publication statusPublished - Mar 2007
Externally publishedYes


Dive into the research topics of 'Retinal Vein Occlusion and Vascular Mortality: Pooled Data Analysis of 2 Population-Based Cohorts'. Together they form a unique fingerprint.

Cite this