Retinopathy of prematurity: recent advances in our understanding

C Wheatley, J Dickinson, David Mackey, Jamie Craig, Michele Sale

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Retinopathy of prematurity (ROP) has been recognised as an important cause of childhood visual impairment and blindness since the 1940s when improved facilities and treatment increased the survival rate of premature infants. Although its incidence and severity have been decreasing in developed countries over the past two decades, both are increasing in developing nations. ROP is consequently targeted as an important but avoidable disease. This review provides an updated summary and discussion of much of the work that has been produced through population, animal, cell culture, and genetic research. The authors examine the prevalence, risk factors, and possible causes of the disease with a particular focus on genetic studies. They conclude that while significant reductions in the disease have occurred in developed countries, further research is required to fully understand and prevent the disease. In the meantime, development and implementation of appropriate screening and treatment strategies will be critical in reducing blindness in developing countries.
Original languageEnglish
Pages (from-to)F78-F82
Number of pages5
JournalArchives of Disease in Childhood. Fetal and Neonatal Edition
Issue number2
Publication statusPublished - 2002
Externally publishedYes


  • retinopathy
  • child
  • childhood blindness
  • vision


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