Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

Mariana Oksdath; Sally L. Perrin; Cedric Bardy; Emily F. Hilder; Cole A. Deforest; R. Dario Arrua; Guillermo A. Gomez

doi:10.1063/1.5045124

Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

Mariana Oksdath, Sally L. Perrin, Cedric Bardy, Emily F. Hilder, Cole A. Deforest, R. Dario Arrua, Guillermo A. Gomez

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

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Abstract

Stem cell-derived brain organoids provide a powerful platform for systematic studies of tissue functional architecture and the development of personalized therapies. Here, we review key advances at the interface of soft matter and stem cell biology on synthetic alternatives to extracellular matrices. We emphasize recent biomaterial-based strategies that have been proven advantageous towards optimizing organoid growth and controlling the geometrical, biomechanical, and biochemical properties of the organoid's three-dimensional environment. We highlight systems that have the potential to increase the translational value of region-specific brain organoid models suitable for different types of manipulations and high-throughput applications.

Original language	English
Article number	041501
Number of pages	19
Journal	APL Bioengineering
Volume	2
Issue number	4
DOIs	https://doi.org/10.1063/1.5045124
Publication status	Published - 1 Dec 2018

Keywords

brain organoids
Synthetic scaffolds
stem cell biology

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10.1063/1.5045124Licence: CC BY

Oksdath_Review_P2018Final published version, 4.65 MBLicence: CC BY

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AU - Bardy, Cedric

AU - Hilder, Emily F.

AU - Deforest, Cole A.

AU - Arrua, R. Dario

AU - Gomez, Guillermo A.

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AB - Stem cell-derived brain organoids provide a powerful platform for systematic studies of tissue functional architecture and the development of personalized therapies. Here, we review key advances at the interface of soft matter and stem cell biology on synthetic alternatives to extracellular matrices. We emphasize recent biomaterial-based strategies that have been proven advantageous towards optimizing organoid growth and controlling the geometrical, biomechanical, and biochemical properties of the organoid's three-dimensional environment. We highlight systems that have the potential to increase the translational value of region-specific brain organoid models suitable for different types of manipulations and high-throughput applications.

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Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

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Keywords

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